Ecofucin, 100 mg 20 pcs

Indications
intestinal candidiasis;
acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
sanitation of the intestinal reservoir of fungi of the genus Candida for candidiasis of the skin and mucous membranes, incl. for candidiasis vaginitis, vulvitis, vulvovaginitis.

Composition

Composition per tablet

Active ingredient: 
natamycin (in terms of 100% substance) – 100.00 mg.

Excipients: 
potato starch – 76.50 mg,
povidone K-17 – 13.00 mg,
magnesium stearate – 2.50 mg,
lactose monohydrate – to obtain an uncoated tablet weighing 250.00 mg.

Shell excipients: 
methacrylic acid and ethyl acrylate copolymer (1:1) – 9.29 mg,
talc – 5.52 mg,
povidone K-25 – 2.51 mg,
macrogol-4000 – 1.42 mg,
titanium dioxide – 1 .26 mg.

Pharmachologic effect

Pharmacotherapeutic group: Antifungal agent.

ATX code: A07AA03.


Pharmacological properties

Pharmacodynamics

Antifungal polyene (tetraene) antibiotic of the macrolide group. It has a predominantly fungicidal effect. Natamycin irreversibly binds to ergosterol of the cell membrane of the fungal cell, which leads to a violation of its integrity, loss of cytoplasmic contents and cell death. Most pathogenic yeasts and molds are sensitive to natamycin, including the genera Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Dermatophytes and P. boydii are less sensitive to natamycin. There are no cases of resistance to natamycin in clinical practice. Natamycin in enteric tablet dosage form acts only in the intestinal lumen.

Pharmacokinetics

Natamycin is not absorbed from the gastrointestinal tract and does not have a systemic effect.

Indications

• intestinal candidiasis;
• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
• sanitation of the intestinal reservoir of fungi of the genus Candida for candidiasis of the skin and mucous membranes, incl. for candidiasis vaginitis, vulvitis, vulvovaginitis.

Use during pregnancy and breastfeeding

Contraindications

Side effects

From the digestive system: nausea and diarrhea are possible, occurring in the first days of taking the pills and going away on their own during treatment.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

How to take, course of administration and dosage

Inside. Eating does not affect the effectiveness of the drug.

For intestinal candidiasis, adults are recommended to take 1 tablet 4 times a day, children – 1 tablet 2 times a day. The average duration of treatment is 1 week.

For persistent vaginitis caused by fungi of the genus Candida, Ecofucin® tablets are used together with local antifungal drugs (for example, Ecofucin® suppositories) to sanitize the focus of candidiasis infection in the intestines (1 tablet orally 4 times a day for 10-20 days).

The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.

Special instructions

Patients with rare congenital intolerance to galactose, fructose, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency should take into account that the drug contains lactose monohydrate.

If you have one of the listed diseases, be sure to consult your doctor before taking the drug.

Ecofucin® in this dosage form is not recommended for use in infants due to possible difficulty in swallowing tablets.

Effect on the ability to drive vehicles and machinery 

The drug does not affect the ability to drive vehicles and machinery. 

Storage conditions

In the original packaging (pack) at a temperature not exceeding 25 °C. 
Keep out of the reach of children.

Active substance

Natamycin