Drotaverine Reneval, tablets 40 mg 56 pcs

A myotropic antispasmodic, isoquinoline derivative. By chemical structure and pharmacological properties it is similar to papaverine, but has a stronger and longer action. It reduces influx of calcium ions into smooth muscle cells (inhibits phosphodiesterase, leads to accumulation of intracellular cyclic adenosine monophosphate).

Reduces smooth muscle tone of internal organs and intestinal peristalsis, dilates blood vessels. It does not influence vegetative nervous system. It does not influence central nervous system.

Presence of direct influence on smooth muscles allows to use it as an antispasmodic when drugs from m-cholinoblocker group are contraindicated (closed-angle glaucoma, prostatic hyperplasia).

Pharmacokinetics

When administered orally the absorption is high, period of semi-absorption – 12 min. Bioavailability – 100%. Evenly distributed in tissues, penetrates into smooth muscle cells. Maximal concentration in blood plasma is 2 hours. Plasma protein binding is 95-98%. It is mainly excreted by kidneys, to a lesser extent – with bile. Does not penetrate the blood-brain barrier.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

During treatment, it is necessary to refrain from driving and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Side effects

Overdose

Pregnancy use

Similarities