Drotaverine Reneval, tablets 40 mg 28 pcs

A myotropic antispasmodic, isoquinoline derivative. By chemical structure and pharmacological properties it is similar to papaverine, but has a stronger and longer action. It reduces influx of calcium ions into smooth muscle cells (inhibits phosphodiesterase, leads to accumulation of intracellular cyclic adenosine monophosphate).

Reduces smooth muscle tone of internal organs and intestinal peristalsis, dilates blood vessels. It does not influence vegetative nervous system. It does not influence central nervous system.

Presence of direct influence on smooth muscles allows to use it as an antispasmodic when drugs from m-cholinoblocker group are contraindicated (closed-angle glaucoma, prostatic hyperplasia).

Pharmacokinetics

When administered orally the absorption is high, period of semi-absorption – 12 min. Bioavailability – 100%. Evenly distributed in tissues, penetrates into smooth muscle cells. Maximal concentration in blood plasma is 2 hours. Plasma protein binding is 95-98%. It is mainly excreted by kidneys, to a lesser extent – with bile. Does not penetrate the blood-brain barrier.

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