A myotropic antispasmodic, isoquinoline derivative. It inhibits phosphodiesterase IV, which leads to accumulation of intracellular cyclic adenosine monophosphate and as a consequence to inactivation of myosin light chain kinase, resulting in relaxation of smooth muscles.
Regardless of the type of autonomic innervation, drotaverine acts on smooth muscles in the gastrointestinal tract, biliary, urogenital and vascular systems. In the myocardium and vessels, the enzyme that hydrolyzes cyclic adenosine monophosphate is phosphodiesterase III, which explains the absence of serious cardiovascular side effects and the low therapeutic effect on the cardiovascular system.
Colitis, Gastroduodenitis, Menstrual pain (algodysmenorrhea), Painful menstruation (algodysmenorrhea), Gallstone disease, Pain, Urolithiasis, Colic
– Smooth muscle spasms associated with diseases of the biliary tract (cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, papillitis);
– spasms of the smooth muscles of the urinary tract (nephrolithiasis, urethrolithiasis, pyelitis, cystitis, bladder tenesm).
As adjunctive therapy:
– in spasms of the smooth muscles of the gastrointestinal tract (gastric and duodenal ulcer, gastritis, cardiac and gatekeeper spasms, enteritis, colitis, spastic colitis with constipation and mucous colitis with flatulence);
– tensor headache;
– in gynecological diseases (dysmenorrhea).
The active ingredient:
drotaverine hydrochloride – 40 mg.
Lactose monohydrate (milk sugar) – 63 mg,
Potato starch – 32 mg,
magnesium stearate -1 mg,
talcum powder – 3 mg,
water-soluble methylcellulose – 1 mg.
How to take, the dosage
Ingestion. Adults, 40-80 mg (1-2 tablets) 2-3 times a day.
It enhances the effect of other antispasmodics (including m-cholinoblockers), arterial hypotension caused by tricyclic antidepressants, quinidine, procainamide.
Decreases the spasmogenic activity of morphine and the antiparkinsonian properties of levodopa.
The antispasmodic effect of drotaverine is increased when used concomitantly with phenobarbital.
In the treatment of peptic ulcer disease of the stomach and duodenum it is used in combination with other anti-ulcer drugs.
Hypersensitivity to the active substance or any of the ingredients of the drug, severe renal or hepatic failure, severe heart failure (low cardiac output syndrome), lactation, children under 18 years of age.
Do not take in people with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Gastrointestinal disorders (nausea, constipation), nervous system disorders (headache, dizziness, insomnia); cardiovascular disorders (palpitations, arterial hypotension), allergic reactions (including allergic dermatosis).
Atrioventricular block, cardiac arrest, respiratory center paralysis.
Treatment: drug withdrawal, symptomatic therapy. There is no specific antidote.
No-shpa, Drotaverine, Spasmonet, Drotaverine-Teva
|Conditions of storage|
In a dry place protected from light
Avexima Siberia, Russia
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