Dolonit-MosPharma, gel 30 g

The action of the drug is due to its constituent active ingredients: dimethyl sulfoxide, sodium heparin and dexpanthenol.
Dimethyl sulfoxide (DMSO)

Indications

Swelling, hematomas and inflammation of soft tissues, muscles, tendons, tendon sheaths and ligaments after bruises, compression, injuries;
closed injuries, bruises;
joint injuries with ligament damage;
humeroscapular periarthritis and epicondylitis of the shoulder (“tennis elbow”), tendonitis (inflammation of the tendons), tendovaginitis (inflammation of the tendon sheaths), bursitis (inflammation of the mucous membrane of the joints);
acute neuralgia.

Pharmacological effect

The effect of the drug is due to the active substances included in its composition: dimethyl sulfoxide, sodium heparin and dexpanthenol.
Dimethyl sulfoxide (DMSO)

Special instructions

The drug is used sparingly, quickly penetrates the skin and does not leave a greasy layer on the skin or stains on the laundry. Thanks to the alcohol contained (ethanol), which evaporates after applying the gel, a pleasant cooling sensation is felt at the site of application of the drug. The pleasant cooling effect is enhanced if the gel is stored in the refrigerator, as well as if the drug is used in hot weather (due to increased evaporation of alcohol).

The area of ​​skin to which the drug is applied must be cleaned of dirt, cosmetics, other medications and chemicals.

When using dressings, it is necessary to wait a few minutes after applying the gel so that the bulk of the gel is absorbed and the ethyl alcohol (ethanol) evaporates. This is especially important in cases where a bandage that is poorly permeable to air is used.

During treatment with the drug, the photosensitivity of the skin may increase, so during its use you should limit intense sunbathing and visits to the solarium.

If skin reactions occur, treatment should be discontinued.

Due to the high absorption of dimethyl sulfoxide, Dolonit-MosPharma should not be used in combination with other ointments and gels.

It should be remembered that contact of the drug on open wounds causes a painful reaction, because the gel contains ethyl alcohol (ethanol).

Impact on the ability to drive vehicles and operate machinery

When administered cutaneously, the drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Sodium heparin, Dexpanthenol, Dimethyl sulfoxide

Composition

Gel for external use is colorless, transparent or slightly opalescent, homogeneous, with a characteristic odor.

100 g
heparin sodium
50,000 IU
dexpanthenol
2.5 g
dimethyl sulfoxide
15 g

Excipients:

carbomer homopolymer type C – 1 g,

trometamol – 0.2 g,

macrogol glyceryl hydroxystearate – 0.9 g,

ethanol 95% – 38.06 g,

rosemary oil – 0.2 g,

Scots pine needle oil – 0.25 g,

lemon oil – 0.05 g,

purified water – up to 100 g.

Contraindications

Hypersensitivity to one of the components of the gel (active/excipients);
severe impairment of liver and/or kidney function;
bronchial asthma;
severe disorders of the cardiovascular system (IV functional class of angina pectoris according to the classification of the Canadian Society of Cardiology, myocardial infarction, stroke, severe generalized atherosclerosis);
pregnancy;
breastfeeding period;
children under 5 years of age.

Do not apply the drug to mucous membranes (eyes, nose, mouth), open wounds or damaged skin (for example, conditions after radiation or severe sunburn, fresh post-operative scars).

Side Effects

The drug is usually well tolerated, however, in isolated cases, local skin reactions (redness, itching and burning sensation at the site of application) are possible, which usually gradually disappear during treatment.

Sometimes, due to the content of DMSO or other components of the drug, a general allergic skin reaction with urticaria and Quincke’s edema may occur.

In rare cases, while using the drug, some patients may experience a garlic odor from the mouth, which is due to the presence of dimethyl sulfide, a metabolite of dimethyl sulfoxide.

This smell indicates good absorption of dimethyl sulfoxide. Some patients may experience a change in taste after applying the gel, which disappears after a few minutes.

It is extremely rare that when applying the drug to large areas of the body, nausea, diarrhea, difficulty breathing, headache, and chills may occur.

Interaction

Local use of other drugs simultaneously with the drug Dolonit-MosPharma contributes to a sharp increase in their permeability through the skin.

When used simultaneously with the non-steroidal anti-inflammatory drug sulindac, the development of peripheral neuropathy is possible (due to the presence of dimethyl sulfoxide in the composition of the drug Dolonit-MosPharma).

Overdose

Cases of overdose and poisoning with the drug have not been described.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf life

3 years.

Manufacturer

Moscow pharmaceutical factory, Russia