Diuver, tablets 5 mg 20 pcs

Pharmacotherapeutic group: diuretic agent.

AtCode C03CA04

Pharmacological properties

Pharmacodynamics

Indications

Active ingredient

Composition

1 tablet 5 mg contains:

active ingredient: torasemide 5.00 mg;

excipients: lactose monohydrate 58.44 mg, corn starch 14.56 mg, sodium carboxymethyl starch 0.80 mg, colloidal anhydrous silica 0.60 mg, magnesium stearate 0.60 mg.

1 tablet 10 mg contains:

acting substance: torasemide 10.00 mg;

complementary substances: lactose monohydrate 116.88 mg, corn starch 29.12 mg, sodium carboxymethyl starch 1.60 mg, colloidal anhydrous silica 1.20 mg, magnesium stearate 1.20 mg.

How to take, the dosage

Overly, once a day, after breakfast, with a small amount of water.

Oedematous syndrome of different genesis, including. In chronic heart failure, liver, lung and kidney disease

The usual therapeutic dose is 5 mg orally once daily. If necessary, the dose should be gradually increased to 20-40 mg once daily, in some cases up to 200 mg per day. The drug is prescribed for a long period or until the edema disappears.

Arterial hypertension

The initial dose is 2.5 mg (1/2 tablet of 5 mg) once daily. If necessary, the dose may be increased to 5 mg once daily.

Elderly patients do not need dose adjustment.

Interaction

Special Instructions

Synopsis

Dosage 5 mg:

White or almost white round biconvex tablets with a bevel on one side and engraved “915” on the other side.

Dosage 10 mg:

White or almost white round biconvex tablets with a bevel, with a groove on one side and engraving “916” on the other side.

Contraindications

Side effects

Water-electrolyte and acid-base balance: hyponatremia, hypochloremia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis. Symptoms indicative of the development of electrolyte and acid-base state disorders may include headache, confusion, seizures, tetany, muscle weakness, heart rhythm disorders and dyspeptic disorders; hypovolemia and dehydration (more common in elderly patients), which may lead to hemoconcentration with a tendency to develop thrombosis.

Cardiovascular system disorders: excessive decrease in blood pressure, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased circulating blood volume.

Metabolic side: Hypercholesterolemia, hypertriglyceridemia; transient increase in blood creatinine and urea concentrations; increase in blood uric acid concentration, which may cause or worsen manifestations of gout; decrease in glucose tolerance (possible manifestation of latent diabetes).

Urinary system disorders: oliguria, acute urinary retention (e.g., in prostatic hyperplasia, narrowing of the urethra, hydronephrosis); interstitial nephritis, hematuria, decreased potency.

Gastrointestinal tract disorders: nausea, vomiting, diarrhea, intrahepatic cholestasis, increased activity of “liver” enzymes, acute pancreatitis.

Central nervous system, hearing: disorder of hearing, usually reversible, and/or tinnitus, especially in patients with renal failure or hypoproteinemia (nephrotic syndrome), paresthesias.

Skin side: cutaneous itching, urticaria, other rashes or bullous skin lesions, erythema polymorphicum, exfoliative dermatitis, purpura, fever, vasculitis, eosinophilia, photosensitization; severe anaphylactic or anaphylactoid reactions up to shock, which so far have only been described after intravenous administration.

Peripheral blood: thrombocytopenia; leukopenia; agranulocytosis, aplastic or hemolytic anemia.

Overdose

Pregnancy use

Toracemide has no teratogenic effect and fetotoxicity, it penetrates the placental barrier, causing water-electrolyte metabolism disorders and thrombocytopenia in the fetus.

Diuver during pregnancy should be used only if the benefit to the mother outweighs the possible potential risk to the fetus, only under medical supervision and only in the lowest possible doses.

It is unknown whether thoracemide penetrates into the breast milk. If it is necessary to use the drug Diuver during lactation, breastfeeding should be stopped.

Similarities