Diprosalik, ointment 30 g

Diprosalik is an anti-inflammatory, antipruritic, anti-allergic, keratolytic, antimicrobial agent. Diprosalik is a combined preparation based on two active substances – betamethasone dipropionate and salicylic acid.

Betamethasone dipropionate is a glucocorticosteroid and has anti-inflammatory, anti-allergic and antipruritic effects.

Salicylic acid has keratolytic, as well as antimicrobial and antifungal properties when used topically.

Indications

To reduce the inflammatory manifestations of dry and hyperkeratotic dermatoses, sensitive to GCS therapy, including:

psoriasis;
chronic atopic dermatitis;
neurodermatitis (chronic lichen simplex);
lichen planus;
eczema (coin-shaped, hand eczema, eczematous dermatitis);
dyshidrosis;
seborrheic dermatitis of the scalp;
ichthyosis and ichthyotic lesions.

Pharmacological effect

Diprosalik is an anti-inflammatory, antipruritic, antiallergic, keratolytic, antimicrobial agent. Diprosalik is a combination drug based on two active substances – betamethasone dipropionate and salicylic acid.

Betamethasone dipropionate is a glucocorticosteroid that has anti-inflammatory, antiallergic and antipruritic effects.

Salicylic acid, when applied topically, has keratolytic, as well as antimicrobial and antifungal properties.

Special instructions

If dryness, skin irritation or hypersensitivity occurs, you should stop using the drugs. In case of infection, appropriate therapy must be prescribed. With topical use of GCS, especially in children, side effects characteristic of systemic GCS may develop, incl. suppression of the function of the adrenal cortex.

Systemic absorption of GCS and salicylic acid when applied topically will be higher when using occlusive dressings, as well as if large surfaces of the body are treated. Appropriate precautions must be taken if long-term use of drugs is expected (especially in children).

With long-term treatment, drug withdrawal should be carried out gradually.

The ointment and lotion are not intended for ophthalmic use. Contact with eyes and mucous membranes should be avoided.

Do not use lotion under occlusive dressings.

Application of the drug to an open wound or damaged skin is not allowed.

Use in pediatrics

The drug can be used with caution in children over 2 years of age.

Children are more at risk of suppressing the function of the hypothalamic-pituitary-adrenal axis due to the use of local corticosteroids than adults, due to their greater ratio of body surface area to weight and, accordingly, increased absorption of the drug.

There have been reports of suppression of the function of the hypothalamic-pituitary-adrenal system, Cushing’s syndrome, growth retardation, delayed weight gain, and increased intracranial pressure in children receiving topical corticosteroids.

Suppression of the function of the hypothalamic-pituitary-adrenal system in children is determined by low plasma cortisol levels and lack of response to ACTH stimulation. Increased intracranial pressure is manifested by protrusion of the fontanelle, headaches, and bilateral papilledema.

Active ingredient

Betamethasone, Salicylic acid

Composition

1 g ointment contains:

Active substances:

betamethasone dipropionate 0.64 mg;

salicylic acid 30 mg;

Excipients:

liquid paraffin;

petrolatum.

Pregnancy

Due to the fact that the safety of the use of local corticosteroids during pregnancy has not been established, the prescription of this class of drugs is justified only if the potential benefit to the mother outweighs the potential risk to the fetus.

Drugs in this class should not be used during pregnancy in high doses or for long periods of time.

Since it has not yet been determined whether the level of systemic absorption of GCS is sufficient for the appearance of detectable concentrations in breast milk, either breastfeeding or the use of the drug should be stopped during treatment, taking into account how necessary it is for the mother.

Contraindications

Hypersensitivity to any component of the drug.

Side Effects

Burning, itching, irritation and dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis; when using occlusive dressings – maceration and atrophy of the skin, secondary infection, stretch marks, prickly heat.

Salicylic acid preparations can cause dermatitis.

With local use of GCS for a long period and/or in high doses, especially in children, side effects characteristic of systemic GCS may develop (including suppression of the function of the hypothalamic-pituitary-adrenal system, the development of Cushing’s syndrome, growth retardation, insufficient weight gain and increased intracranial pressure).

Overdose

Symptoms: excessive or prolonged use of topical corticosteroids can cause depression of the hypothalamic-pituitary-adrenal axis, leading to secondary adrenal insufficiency and hypercortisolism, including Cushing’s disease.

Long-term use of topical salicylic acid preparations in high doses may cause symptoms of salicylate poisoning (early symptoms include nausea and vomiting).

Treatment: symptomatic therapy. Acute symptoms of hypercortisolism are usually reversible. If necessary, correct electrolyte imbalance.

In case of poisoning with salicylic acid, it is necessary to take measures to quickly remove salicylic acid from the body, for example, ingesting sodium bicarbonate (to alkalinize urine and force diuresis).

Storage conditions

In a dark place, at a temperature of 2–30 °C

Shelf life

5 years

Manufacturer

Schering-Plau Labeau N.V., Belgium