Dioxidin, 10 mg/ml 10 pcs

A broad spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity against infections caused by Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp, Staphylococcus spp., Streptococcus spp., pathogenic anaerobes (Clostridium perfringens), acts on bacterial strains resistant to other chemopreparations, including antibiotics.

The development of drug resistance of bacteria is possible. Treatment of burn and purulent-necrotic wounds promotes faster clearing of the wound surface, stimulates reparative regeneration and marginal epithelization and favourably influences the course of the wound process.

In local application it is partially absorbed from the wound or burn surface and excreted by the kidneys.

In local application it is partially absorbed from the wound or burn surface and excreted by the kidneys.

Indications

Purulent bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.

Intracavitary administration – purulent processes in the thoracic and abdominal cavities, in purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, pelvic cell phlegmon, post-operative wounds of the urinary and biliary tracts, purulent mastitis and others).It is also used for prevention of infectious complications after bladder catheterization. Local application – treatment of acute suppurative otitis media with perforation and exacerbation of chronic suppurative otitis media, treatment of acute tonsillopharyngitis, treatment of exacerbation of chronic tonsillitis (compensated form).

Application: superficial and deep wounds of various localizations, nonhealing wounds and trophic ulcers, soft tissue phlegmons, infected burns, septic wounds at osteomyelitis.

Composition

Active ingredient: hydroxymethylquinoxalindioxide (dioxidine) – 10 mg

Supplementary substance: water for injection – up to 1 ml

How to take, the dosage

Dioxidine is prescribed in the hospital setting. It is used externally, intracavitary. 1% Dioxidin solution cannot be used for intravenous administration due to instability of the solution when stored at low temperatures.

Intracavitary administration. In the pus cavity, depending on its size, 10 to 50 ml of 1% Dioxidine solution is administered per day. Dioxidine solution is injected into the cavity through a catheter, drain tube or syringe. Maximum daily dose for administration in the cavity is 70 ml of 1% solution. The drug is usually injected into the cavity once a day. It is possible to administer a daily dose in two doses according to indications. If tolerated well, the drug can be administered daily for 3 weeks or more. If necessary repeated courses are carried out in 1-1.5 months.

Local administration. In treatment of acute purulent media otitis with perforation and exacerbation of chronic purulent media otitis 0.25 % solution of Dioxidine is used. To obtain 0.25% solution ampoule solutions of the drug is diluted to the required concentration with sterile 0.9% sodium chloride solution or water for injections at a ratio of 1:3 (1 part of Dioxidine solution and 3 parts of sodium chloride solution or water for injections). The solution shall be prepared in a glass or plastic container. The resulting 0.25% solution is dripped into the external auditory canal with a dropper 5 drops of the solution 3 times a day. Duration of treatment for acute suppurative otitis media and exacerbation of chronic suppurative otitis media is 10 days (if clinical improvement is achieved the course of treatment may be 6-8 days). The solution should be put into the patient lying on his side; after the procedure the patient should stay in the same position for several minutes, it is allowed to place a cotton turunda in the external auditory canal.

In treatment of acute tonsillopharyngitis and acute chronic tonsillitis 0.1 % solution of Dioxidine is used. To obtain 0.1% solution ampoule solutions of the drug are diluted to the required concentration with sterile 0.9% sodium chloride solution or water for injections at a ratio of 1:9 (1 part of Dioxidine solution and 9 parts of sodium chloride solution or water for injections). The resulting 0.1% solution is used to wash the tonsils with a syringe or rinse 3 times a day. For one procedure 50 ml of the solution is used. The course of treatment is 7 days.

Application. 0.1-1% solutions of Dioxidine are used. To obtain 0.1-0.2% solutions ampoule solutions of the drug are diluted to the desired concentration with sterile 0.9% sodium chloride solution or water for injection. For treatment of superficial infected septic wounds, napkins moistened with 0.5-1% Dioxidine solution are applied to the wound. Deep wounds after treatment are loosely tamponized with tampons moistened with 1% solution of Dioxidine, and if there is a drainage tube 20 to 100 ml of 0.5% solution of the drug is injected into the cavity.

To treat deep purulent wounds in osteomyelitis (wounds of the hand, foot) 0.5-1% solutions of the drug are used in the form of baths or a special wound treatment with the drug solution for 15-20 minutes (introduction of the solution into the wound for this period) with subsequent application of dressings with 1% Dioxidin solution.

Dioxidine in the form of 0.1-0.5% solutions can be used for prevention and treatment.

Special Instructions

Dioxidine is administered to adults only. Before the start of treatment a test for tolerance of the drug is carried out, for which 10 ml of 1% solution is injected into the cavity. If there are no side effects within 3-6 hours (dizziness, chills, increased body temperature), the course of treatment is started.

Dioxidine is prescribed only in severe forms of infectious diseases or when other antibacterial drugs, including cephalosporins of II-IV generations, fluoroquinolones, carbapenems are not effective. In chronic renal failure, the dose is reduced. If pigmented spots appear, increase the duration of administration of the dose to 1.5-2 hours, decrease the dose, prescribe antihistamines or cancel Dioxidine.

If crystals precipitate during storage (at temperatures below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath while shaking until the crystals dissolve (clear solution). If the crystals do not precipitate again when cooling to 36-38°C, the drug is suitable for use.

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use