Dimexide, concentrate 100 ml

Dimexide is an anti-inflammatory agent with local analgesic and anti-inflammatory effect. It has a moderate antiseptic and fibrinolytic effect.

Dimethylsulfoxide inhibits inflammatory tissue infiltration. In addition, dimethylsulfoxide promotes normalization of fibrin formation processes, increases microcirculation in tissues by inhibiting erythrocyte aggregation, increases phagocyte activity, inhibits neutrophil chemotaxis and decreases circulating immune complexes.

It penetrates through skin, mucous membranes, cell wall of bacteria (increases their sensitivity to antibiotics) and other biological membranes and increases their permeability to drugs. The drug is slightly toxic.

Pharmacokinetics

Dimethylsulfoxide is detected in blood serum after 8-15 minutes by application of the drug, the maximum content is noted after 2-8 hours. As a rule, after 30-36 hours dimethylsulfoxide is no longer detectable in the serum. Dimethylsulfoxide does not cumulate. When the drug is applied topically, dimethylsulfoxide penetrates into the joint cavity and binds to proteins in blood and tissues.

Dimethylsulfoxide is excreted unchanged from the body through the kidneys and as oxidation products – dimethylsulfone and dimethylsulfate; it is also excreted with exhaled air as a reduced product (dimethylsulfide).

Indications

Active ingredient

Composition

Per 100 ml:

The active ingredient:

Dimethoxide (dimethyl sulfoxide) – 100 ml.

How to take, the dosage

Externally, in the form of compresses, swabs, dressings (including occlusive). Usually 30-50% solutions are used.

In treatment of rust and trophic ulcers it is taken in 50-100 ml of 30-50% solution 2-3 times a day;

In eczema, scleroderma it is taken in 40-50% solution compresses;

In pustular skin diseases it is taken in 40% solution.

For local pain relief in pain syndromes – compress with 100-150 ml of 25-50% solution 2-3 times a day;

In the treatment of deep burns – bandages with 20-30% solution.

Interaction

Increases penetration through the skin of drugs (NSAIDs, antibiotics, etc.), which leads to an increase in their activity, in some combinations – to toxicity.

Special Instructions

With the possibility of individual intolerance to the drug, it is recommended to conduct a drug test for tolerance to it. To do this, a thin layer of gel is applied to the skin at the bend of the elbow. The appearance of sudden redness and itching indicates hypersensitivity to Dimexid.

If allergic reactions occur during treatment with the drug, the drug is stopped and H1-histamine receptor blockers are prescribed.

Contraindications

With caution: Due to the fact that Dimethoxid can increase not only the activity but also the toxicity of some drugs, caution should be exercised when prescribing it simultaneously with other drugs.

Side effects

When using the drug, contact dermatitis, garlic breath odor, increased skin pigmentation, allergic reactions, erythematous rashes, dry skin, mild burning sensation may be observed.

Some patients poorly perceive the smell of the drug (nausea, urge to vomit), bronchospasm is possible in single cases.

If any of the side effects listed in the instructions worsen or any other side effects not listed in the instructions occur, you should tell your doctor.

Overdose

Symptoms: intensification of dose-dependent side effects.

Treatment: In these cases, the drug should be withdrawn, the injured area should be flushed, and the drug should be removed.

Pregnancy use