Dimefosfon, 15% 100 ml

Antiacidemic agent, normalizes acid-base state in acidosis of various etiology by activation of metabolic mechanisms of its regulation (especially renal and pulmonary), intraorganic blood flow and tissue metabolism. Cerebrovasodilatory, nootropic, antidepressant, anti-edema, anti-ischemic, stress-protective, mnemotropic, anti-amnestic, anti-allergic, membrane stabilizing, immunomodulatory, antihypoxant, antimutagenic and radioprotective effects, inhibits platelet aggregation, stimulates tissue regeneration.

Dose-dependently decreases the intensity of lipid peroxidation, inhibits spontaneous and ADP-induced aggregation, increases antioxidant activity of platelets and decreases their content of lipid peroxidation products.

It improves cerebral blood circulation, normalizes the tone of cerebral vessels and brain blood flow, improves venous outflow. Neurotropic activity and cerebroprotective properties are caused by the influence on neurometabolic brain defense mechanisms (normalizes carbohydrate and energy metabolism, prevents the activation of lipid peroxidation, increases the activity of antioxidant enzymes in the brain tissue).

In case of traumatic brain injury it has a favorable effect on its metabolism and electrical activity; it eliminates vasomotor cephalgia; reduces oxygen consumption by brain tissue, cardiac and respiratory failure of central genesis, helps regress focal hemispheric and trunk symptoms. It eliminates allergic inflammation, particularly in the development of leukotriene-dependent sulfite intolerance reaction, reduces the severity of manifestations of atopic bronchial asthma and atopic dermatitis. Combined with vitamins, pancreatic enzymes and colestiramine in children with hereditary entero-oxaluria syndrome it slows down the disease progression and increases life time.

When used topically it produces antiseptic effect and increases protective functions of skin and mucosa.

Indications

Pollinosis, Concussion and other brain injuries, Purulent wounds, Meniere’s disease, Dermatitis, Common acne (vulgar), Bronchial asthma, Allergy

• acidosis, pneumonia, chronic lung diseases, acute respiratory infections, diabetes, postoperative period Acidosis in pneumonia, chronic lung disease, acute respiratory infections, diabetes and in the postoperative period;
• bronchospastic variant of bronchial obstruction (chronic bronchitis, bronchial asthma, including.ч.
• bronchial obstruction (chronic bronchitis, bronchial asthma including atopic bronchial asthma in children)
• subcompensated hypertension in the “small” circulatory system
• pollenosis in children
• pollenosis in children.
• Transient ischemic attacks, ischemic and hemorrhagic stroke (initial manifestations, after-effects of previous stroke);
• dyscirculatory encephalopathy (incl.ч.
• dyscirculatory encephalopathy (including against arterial hypertension);
• myelopathy, radiculopathy;
• neurosurgical surgical trauma of brain and spinal cord;
• cranial trauma (brain concussion and contusion);
• Meniere’s syndrome and disease, autonomic lability;
• atopic dermatitis;
• infectious inflammatory diseases of the skin and mucous membranes: acne, rust, pus-inflammatory complications at the Ilizarov apparatus wire exit points;
• diseases of ENT organs and dentistry;
• mucositis in radiation therapy of malignant tumors
• infected wounds, trophic ulcers
• rachitis-like diseases in children
• hereditary entero-oxaluric syndrome.

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Active ingredient

Dimethyloxobutylphosphonyl dimethylate

Composition

Active substances:

dimethyloxobutylphosphonyl dimethylate 15 g.

Auxiliary substances:

water purified to 100 ml.

How to take, the dosage

• internal (children recommended with milk, fruit juice, sweet tea has a bitter taste), 30-50 mg/kg 1-4 times a day: for cerebral circulatory disorders and Meniere’s syndrome – for 1-4 weeks, for planned neurosurgical operations – 5 days before and 10-14 days after surgery, for craniocerebral trauma – 3-8 weeks
• In autonomic dysfunction, respiratory diseases, acidosis, atopic bronchial asthma (in children) – 2-4 weeks
• for the prevention of allergic reactions – 3 weeks before the expected seasonal worsening and during the allergen flowering.

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Special Instructions

If drowsiness occurs, refrain from driving or engaging in activities that require increased attention and reaction time.

Contraindications

• hypersensitivity,
• CPR II-III stage,
• Epilepsy

Side effects

• nausea,
• vomiting,
• pepburn,
• somnia (early in treatment)