Dicloran Plus, gel 30 g

Dicloran Plus – anti-inflammatory topical, analgesic.

Pharmacodynamics

NSAIDs for external use. It has topical analgesic, anti-inflammatory and anti-exudative effects. Diclofenac sodium and methyl salicylate are NSAIDs, whose mechanism of action is due to inhibition of GH synthesis. When applied topically, they reduce pain and inflammation in the joints, morning stiffness and joint swelling, and increase range of motion.

The main component of flax oil is α-linolenic acid which also has anti-inflammatory effects.

Levomenthol irritates the nerve endings, has a local distracting and mild analgesic effect, and causes a feeling of coolness in the area where it is applied.

Pharmacokinetics

When applied topically, diclofenac sodium, methyl salicylate and linseed oil are absorbed and penetrate into the subcutaneous tissue, muscle tissue and joint capsule.

Indications

Active ingredient

Composition

Active substances:

diclofenac diethylamine 11.61 mg;

levomenthol 50 mg;

methylsalicylate 100 mg;

Associates:

butylhydroxyanisole, 0.2 mg;

butylhydroxytoluene, 2 mg;

benzyl alcohol, 10 µl;

dinatrium edetate, 1 mg;

diethylamine, 7.1 µl;

p>carbomer 980 – 10.8 mg;

citric acid monohydrate – 1 mg;

macrogoal glyceryl hydroxystearate (Cremophor RH-40) – 35 mg;

propylene glycol – 100 mg;

water – mod. up to 1 g

How to take, the dosage

Externally. The drug is applied to the skin 3-4 times a day and lightly rubbed on adults and children over 12 years of age. The required amount of the drug depends on the size of the painful area. A single dose of the drug is 2-4 g (4-8 cm with the tube neck completely open). For children from 6 to 12 years old use 2 times a day at the most, a single dose of the drug is up to 2 g.

The duration of treatment without medical advice should not exceed 10 days.

The question about the possibility of longer use of the drug is decided by the doctor on an individual basis.

Interaction

Diclofenac may increase the effect of drugs that cause photosensitization.

Clinically significant interaction with other drugs has not been described.

Special Instructions

The drug should be applied only to intact skin, avoiding contact with open wounds. Dicloran Plus should not be used under an occlusive dressing.

Dicloran Plus should not get in the eyes or on the mucous membranes.

Contraindications

With caution: the drug should be used in patients with severe liver and kidney function disorders, bronchial asthma, in the I and II trimesters of pregnancy and in patients of advanced age.

Side effects

Local reactions: eczema, photosensitization, contact dermatitis (itching, redness, swelling of the treated skin area, papules, vesicles, peeling).

Systemic reactions: generalized skin rash, allergic reactions (urticaria, angioedema, bronchospastic reactions).

Overdose

Symptoms: When applied externally in the recommended doses, the extremely low systemic absorption of the active ingredients of the drug makes overdose almost impossible. Inadvertent ingestion may cause systemic side effects.

Treatment in case of ingestion: gastric lavage, induction of vomiting, administration of activated charcoal, forced diuresis, symptomatic therapy. Dialysis is ineffective due to high degree of binding of diclofenac to plasma proteins (about 99%).

Pregnancy use

The drug is contraindicated in the III trimester of pregnancy. The use of the drug in I and II trimesters of pregnancy is solved individually.

In the absence of experience of using Dicloran® Plus during lactation, the use of the drug during this period is contraindicated.

Similarities