Diclogen, gel 5% 30 g

Diclogen has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.

The mechanism of action is associated with inhibition of COX activity – the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins that play a major role in the pathogenesis of inflammation, pain and fever.

The analgesic effect of Diclogen is caused by two mechanisms: peripheral (indirectly, through inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in central and peripheral nervous system).

Indications

Joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, periarthropathy), post-traumatic inflammation of the soft tissue and musculoskeletal system (sprains, bruises).

Pain in the spine, neuralgia, myalgia, arthralgia, pain and inflammation after surgery and trauma, pain syndrome with gout, migraine, algodysmenorrhea, pain syndrome with adnexitis, proctitis, colic (biliary and renal), pain syndrome with inflammatory diseases of the ENT organs.

Active ingredient

Composition

1 g of gel contains:

diclofenac sodium 5 mg

How to take, the dosage

Diclogen is used externally in a dose of 2-4 g (depending on the area of the painful area) to the affected area 3-4 times a day.

Special Instructions

Avoid getting Diclogen gel in the eyes and on the mucous membranes.

Contraindications

Errotic and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, blood disorders of unclear etiology, hypersensitivity to diclofenac and components of the used dosage form, or other NSAIDs.

Side effects

Gastrointestinal system: nausea, vomiting, anorexia, pain and discomfort in epigastric region, flatulence, constipation, diarrhea; in some cases – erosive ulcerative lesions, bleeding and perforations of the gastrointestinal tract; rarely – liver function disorders. In rectal administration in single cases there have been cases of inflammation of the colon with bleeding, exacerbation of ulcerative colitis.

CNS and peripheral nervous system disorders: dizziness, headache, agitation, insomnia, irritability, fatigue; rarely – paresthesia, visual disturbances (blurring, diplopia), tinnitus, sleep disorders, seizures, irritability, tremor, mental disorders, depression.

With the hematopoietic system: rarely – anemia, leukopenia, thrombocytopenia, agranulocytosis.

Additional disorders of the urinary system: rarely – renal dysfunction; edema is possible in predisposed patients.

Dermatological reactions: rarely – hair loss.

Allergic reactions: skin rash, itching; when used in the form of eye drops – itching, redness, photosensitization.

Local reactions: at the site of injection in/m may burn, in some cases – formation of an infiltrate, abscess, necrosis of adipose tissue; with rectal administration, local irritation, the appearance of mucous discharge with a mixture of blood, painful defecation are possible; with external use in rare cases – itching, redness, rash, burning; with local use in ophthalmology, a transient burning feeling and/or temporary blurred vision immediately after the injection is possible.

Similarities