Diclofenac, gel 1% 40 g

Non-steroidal anti-inflammatory drug, a derivative of phenylacetic acid, has anti-inflammatory and analgesic effect.

Indiscriminately inhibiting cyclooxygenase 1 (COX1) and cyclooxygenase 2 (COX2), affects the metabolism of arachidonic acid, reduces the number of prostaglandins (Pg) in the inflammation.

Pharmacokinetics

When applied topically it is partially absorbed through the skin, bioavailability – 6%.

Plasma protein binding is 99.7%. It is excreted by kidneys.

In patients with polyarthritis who receive local therapy (in the area of the inflamed joint), the concentration in synovial fluid and tissue is higher than the concentration in plasma.

Indications

Active ingredient

Composition

How to take, the dosage

Externally.

Adults and children over 12 years of age apply the drug in a thin layer over the area of inflammation 3-4 times a day and rub in gently.

The amount of product needed depends on the size of the painful area. A single dose of the drug: 2-4 g (which is comparable in volume to the size of a large cherry tree).

Wash your hands after applying the product.

The duration of treatment depends on the indication and the therapeutic effect.

After 2 weeks of use, a doctor should be consulted.

Interaction

Simultaneous use of the drug Diclofenac with digoxin, phenytoin or lithium drugs may increase plasma concentrations of these drugs; with diuretics and hypotensive agents

Diclofenac with potassium-saving diuretics may cause hyperemia; with acetylacetic acid – decreased plasma concentrations of diclofenac decrease in the effect of these drugs; with potassium-saving diuretics – possible development of hyperkalemia; with acetylsalicylic acid – decrease of plasma concentration of diclofenac and increased risk of side effects.

Diclofenac may increase the toxic effects of cyclosporine on the kidneys.

Diclofenac may cause hypo- or hyperglycemia, therefore concomitant use with hypoglycemic agents requires control of blood glucose concentration.

When using methotrexate for 24 hours before or after taking Diclofenac it is possible to increase the concentration of methotrexate and increase its toxic effect.

When concomitant use with anticoagulants, regular monitoring of blood clotting is necessary.

Special Instructions

Contraindications

Side effects

Skin disorders:

Eczema, photosensitization, contact dermatitis (itching, hyperemia, swelling of the treated skin area, papular vesicular rash, peeling).

Allergic reactions

(skin itching and burning, erythematous skin rash, urticaria, angioedema, systemic anaphylactic reactions (including shock).

Similarities