Diclofenac Altfarm, rectal 50 mg 10 pcs

Diclofenac – analgesic, anti-aggregative, antipyretic, anti-inflammatory.

Blocks cyclooxygenase, reduces the synthesis of PG and thromboxanes, suppresses the exudative and proliferative phases of inflammation.

Decreases the amount of serotonin, histamine and bradykinin, increases the threshold of sensitivity of pain receptors: reduces the concentration of PG in the hypothalamic thermoregulation center, increases the heat output.

Pharmacokinetics

It is well absorbed in the gastrointestinal tract, in plasma it is almost completely bound by blood proteins (66-99%). It quickly penetrates into tissues and synovial fluid, where it persists for 4-6 hours longer than in blood. T1/2 is 1.1-2 hours. Metabolized in the liver. It is excreted with urine (65%) and bile (35%).

Indications

Rheumatoid arthritis, ankylosing spondylitis, osteoarthritis deformans, periarticular inflammation, post-traumatic inflammatory and painful conditions of soft tissues and joints, tendovaginitis, neuritis, synovitis, acute muscle pain, neuralgia, back pain and toothache.

Pharmacological effect

Diclofenac – analgesic, antiaggregation, antipyretic, anti-inflammatory.

Blocks cyclooxygenase, reduces the synthesis of PG and thromboxanes, suppresses the exudative and proliferative phases of inflammation.

Reduces the amount of serotonin, histamine and bradykinin, increases the sensitivity threshold of pain receptors: reduces the concentration of PG in the thermoregulation center of the hypothalamus, increases heat transfer.

Pharmacokinetics

Well absorbed from the gastrointestinal tract, in plasma it is almost completely bound by blood proteins (66–99%). It quickly penetrates into tissues and synovial fluid, where it persists 4–6 hours longer than in the blood. T1/2 – 1.1–2 hours. Metabolized in the liver. Excreted in urine (65%) and bile (35%).

Special instructions

Avoid getting Diclofenac ointment (gel) on damaged skin surfaces, open wounds, eyes and mucous membranes.

The use of Diclofenac in the form of an ointment is possible only as prescribed by a doctor in the following cases: a history of gastric and duodenal ulcers; liver and kidney dysfunction; severe disorders of the hematopoietic system; bronchial asthma, rhinitis, polyps of the nasal mucosa; history of allergic reactions.
Use the drug with caution simultaneously with other NSAIDs.

Use in pediatrics

If it is necessary to use the drug in the form of an ointment in children under 6 years of age, medical supervision is required.

Effect on the ability to drive a car and operate machinery

Due to the fact that when using the drug in high doses, side effects such as dizziness and fatigue may develop, in some cases the ability to drive a car or other moving objects is impaired. These phenomena are enhanced by simultaneous intake of alcohol.

Active ingredient

Diclofenac

Composition

Active ingredient:

diclofenac 50 mg;

Excipients:

1,2-propylene glycol,

aerosil,

vitepsol

Pregnancy

Use during pregnancy and lactation is possible in cases where the potential benefit to the mother outweighs the potential risk to the fetus or newborn.

Contraindications

Hypersensitivity, gastric and duodenal ulcers, bronchial asthma, cardiovascular failure, arterial hypertension, liver and kidney diseases, childhood and adolescence (up to 12 years), pregnancy, lactation (breastfeeding should be avoided).

Side Effects

From the digestive system: nausea, vomiting, epigastric pain, anorexia, flatulence, constipation, gastritis up to erosive with bleeding, increased transaminase activity, drug-induced hepatitis, pancreatitis.

From the urinary system: interstitial nephritis.

From the side of the central nervous system: headache, dizziness, disorientation, agitation, insomnia, irritability, fatigue, aseptic meningitis.

From the respiratory system: bronchospasm.

From the hematopoietic system: anemia, thrombocytopenia, leukopenia, agranulocytosis.

Dermatological reactions: exanthema, erythema, eczema, hyperemia, erythroderma, photosensitivity.

Allergic reactions: erythema multiforme, Lyell’s syndrome, Stevens-Johnson syndrome, anaphylactic reactions, including shock.

Local reactions: burning, formation of infiltrate, and necrosis of adipose tissue are possible at the injection site.

Other: fluid retention in the body, edema, increased blood pressure.

Interaction

With the simultaneous use of Diclofenac with digoxin, phenytoin or lithium preparations, it is possible to increase the plasma concentrations of these drugs; with diuretics and antihypertensive drugs – the effect of these drugs may be reduced; with potassium-sparing diuretics – hyperkalemia may develop; with acetisalicylic acid – a decrease in the concentration of diclofenac in the blood plasma and an increased risk of side effects.

Diclofenac may enhance the toxic effect of cyclosporine on the kidneys.

Diclofenc can cause hypo- or hyperglycemia, therefore, when used simultaneously with hypoglycemic agents, monitoring of blood glucose concentrations is required.

When using methotrexate within 24 hours before or after taking Diclofenac, the concentration of methotrexate may increase and its toxic effect may increase.

When used simultaneously with anticoagulants, regular monitoring of blood clotting parameters is necessary.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 C. Store out of the reach of children.

Shelf life

2 years.

Manufacturer

Altfarm, Russia