Diclofenac – analgesic, anti-aggregative, antipyretic, anti-inflammatory.
Blocks cyclooxygenase, reduces the synthesis of PG and thromboxanes, suppresses the exudative and proliferative phases of inflammation.
Decreases the amount of serotonin, histamine and bradykinin, increases the threshold of sensitivity of pain receptors: reduces the concentration of PG in the hypothalamic thermoregulation center, increases the heat output.
It is well absorbed in the gastrointestinal tract, in plasma it is almost completely bound by blood proteins (66-99%). It quickly penetrates into tissues and synovial fluid, where it persists for 4-6 hours longer than in blood. T1/2 is 1.1-2 hours. Metabolized in the liver. It is excreted with urine (65%) and bile (35%).
Lumbago, Migraine, Neck pain, Gout, Osteoarthritis, Swelling after injuries and operations, Back pain, Bursitis, Arthrosis, Neuralgia, Pain, Sciatica, Adnexitis, Inflamed tendons, Myalgia (muscle pain), Joint pain (arthralgia), Headache, Arthritis, Rheumatoid arthritis, Periarthritis, Toothache<
diclofenac 50 mg;
How to take, the dosage
Rectally. Adults: 100 mg once daily, 50 mg twice daily or 25 mg 3-4 times daily.
The maximum daily dose is 150 mg.
Children over 12 years of age: 50 mg 1-2 times a day or 25 mg 2-3 times a day.
In concomitant use of the drug Diclofenac with digoxin, phenytoin or lithium drugs may increase plasma concentrations of these drugs; with diuretics and hypotensive agents – possible decrease in the effect of these drugs; with potassium-saving diuretics – possible development of hyperkalemia; with acetylsalicylic acid – decrease of diclofenac concentration in blood plasma and increased risk of side effects.
Diclofenac may increase the toxic effects of cyclosporine on the kidneys.
Diclofenac may cause hypo- or hyperglycemia, therefore concomitant use with hypoglycemic agents requires control of blood glucose concentration.
When using methotrexate for 24 hours before or after taking Diclofenac it is possible to increase the concentration of methotrexate and increase its toxic effect.
When concomitant use with anticoagulants regular monitoring of blood clotting is required.
Avoid getting Diclofenac ointment (gel) on the damaged skin surface, open wounds, eyes and mucous membranes.
The use of Diclofenac in the form of ointment is possible only by prescription in the following cases: gastric and duodenal ulcer in the anamnesis; liver and kidney function disorders; expressed disorders of the hematopoietic system; bronchial asthma, rhinitis, polyps of nasal mucosa; allergic reactions in anamnesis.
Use the drug with caution in conjunction with other NSAIDs.
In children under 6 years of age, if it is necessary to use the drug in the form of an ointment, medical supervision is required.
Impact on driving and operating machinery
Because of the possible side effects of high doses of the drug, such as dizziness and fatigue, in some cases the ability to drive or operate a vehicle or other moving objects is impaired. These effects worsen with concomitant use of alcohol.
Hypersensitivity, peptic ulcer, bronchial asthma, cardiovascular insufficiency, arterial hypertension, liver and kidney diseases, childhood and adolescence (under 12 years), pregnancy, lactation (breastfeeding should be stopped).
Digestive system disorders: nausea, vomiting, epigastric pain, anorexia, flatulence, constipation, gastritis up to erosive with bleeding, increased transaminase activity, drug-induced hepatitis, pancreatitis.
Urinary system disorders: interstitial nephritis.
CNS disorders: headache, dizziness, disorientation, agitation, insomnia, irritability, fatigue, aseptic meningitis.
Respiratory system: bronchospasm.
Hematopoietic system disorders: anemia, thrombocytopenia, leukopenia, agranulocytosis.
Dermatological reactions: exanthema, erythema, eczema, hyperemia, erythrodermia, photosensitization.
Allergic reactions: erythema multiforme, Lyell’s syndrome, Stevens-Johnson syndrome, anaphylactic reactions, including shock.
Local reactions: burning, infiltrate formation, necrosis of adipose tissue possible at the injection site.
Others: fluid retention in the body, edema, increased BP.
Pregnancy and lactation are possible when the potential benefit to the mother exceeds the potential risk to the fetus or newborn.
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|Conditions of storage|
Store in a dry, light-protected place at a temperature not exceeding 25 C. Keep out of reach of children.
Buy Diclofenac Altfarm, rectal 50 mg 10 pcs with delivery to USA, UK, Europe and over 120 other countries.