Dibicor, tablets 500 mg 60 pcs
€13.73 €11.44
Dibicor is metabolic.
Pharmacodynamics
Taurine is a natural product of the metabolism of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane-protective properties, has a positive effect on the phospholipid composition of cell membranes, and normalizes the exchange of calcium and potassium ions in cells.
Taurine showed properties of inhibitory neurotransmitter, it has anti-stressor effect, can regulate the release of GABA, adrenaline, prolactin and other hormones and regulate responses to them.
Participating in the synthesis of respiratory chain proteins in mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties; it affects enzymes such as cytochromes responsible for the metabolism of various xenobiotics.
Dibicor® improves metabolic processes in the heart, liver and other organs and tissues.
In chronic diffuse liver diseases Dibicor® increases blood flow and reduces the severity of cytolysis. It reduces congestion in the small and large circulatory system: intracardiac diastolic pressure decreases, myocardial contractility increases (maximal contraction and relaxation rate, contractility and relaxation indices).
The drug moderately decreases BP in patients with arterial hypertension and has almost no effect on BP in patients with CVD with lowered BP.
Dibicor® decreases side effects of overdose of cardiac glycosides and slow calcium channel blockers; decreases hepatotoxicity of antifungal agents. Improves performance under heavy physical activity.
Dibicor® decreases blood sugar level in diabetics about 2 weeks after taking the drug. A significant reduction of triglycerides concentration and, to a lesser degree, of cholesterol level and atherogenicity of plasma lipids is also observed. Long-term use of the drug (about 6 months) showed improvement of the microcirculatory blood flow in the eye.
Pharmacokinetics
After a single use of 500 mg of Dibicor® the active substance (taurine) is determined in blood after 15-20 minutes, Cmax is reached after 1.5-2 hours. The drug is completely eliminated in 24 hours.
Indications
cardiovascular failure of various etiologies;
intoxication caused by cardiac glycosides;
type 1 diabetes mellitus;
diabetes mellitus type 2, incl. with moderate hypercholesterolemia;
as a hepatoprotector in patients taking antifungal drugs.
Pharmacological effect
Dibikor – metabolic.
Pharmacodynamics
Taurine is a natural metabolic product of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane protective properties, has a positive effect on the phospholipid composition of cell membranes, and normalizes the exchange of calcium and potassium ions in cells.
Taurine has been shown to have the properties of an inhibitory neurotransmitter; it has an anti-stress effect, can regulate the release of GABA, adrenaline, prolactin and other hormones, as well as regulate responses to them.
By participating in the synthesis of respiratory chain proteins in mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties; affects enzymes such as cytochromes responsible for the metabolism of various xenobiotics.
Dibikor® improves metabolic processes in the heart, liver and other organs and tissues.
In chronic diffuse liver diseases, Dibikor® increases blood flow and reduces the severity of cytolysis. Treatment with Dibicor® for cardiovascular failure (CVF) leads to a reduction in congestion in the pulmonary and systemic circulation: intracardiac diastolic pressure decreases, myocardial contractility increases (maximum rate of contraction and relaxation, contractility and relaxation indices).
The drug moderately reduces blood pressure in patients with arterial hypertension and has virtually no effect on its level in patients with heart failure with low blood pressure.
Dibikor® reduces side effects that occur with an overdose of cardiac glycosides and blockers of “slow” calcium channels; reduces the hepatotoxicity of antifungal drugs. Increases performance during heavy physical activity.
In case of diabetes mellitus, approximately 2 weeks after starting to take Dibikor®, the blood sugar level decreases. There was also a significant decrease in the concentration of triglycerides, and to a lesser extent, cholesterol levels, and a decrease in the atherogenicity of plasma lipids. With long-term use of the drug (about 6 months), an improvement in the microcirculatory blood flow of the eye was noted.
Pharmacokinetics
After a single dose of 500 mg of Dibikor®, the active substance (taurine) is determined in the blood after 15–20 minutes, Cmax is reached after 1.5–2 hours. The drug is completely eliminated within 24 hours.
Special instructions
While taking Dibikor, the dose of cardiac glycosides should be reduced sometimes by 2 times, depending on the sensitivity of patients to cardiac glycosides.
The same rule applies to blockers of “slow” calcium channels.
Active ingredient
Taurine
Composition
Pills
Active ingredient:
taurine 500 mg;
Excipients:
MCC 46 mg;
potato starch 36 mg;
gelatin 12 mg;
colloidal silicon dioxide (Aerosil) 0.6 mg;
calcium stearate 5.4 mg;
Pack of 30 and 60 pcs.
Pregnancy
Data on the use of the drug during pregnancy and lactation are not provided.
Contraindications
Hypersensitivity to the drug; age under 18 years (efficacy and safety have not been established).
Side Effects
Allergic reactions to the components of the drug are possible.
Interaction
Dibikor® can be used with other drugs; enhances the inotropic effect of cardiac glycosides.
Overdose
There are no data on overdose.
Storage conditions
In a dry place, protected from light, at room temperature
Shelf life
3 years
Manufacturer
Pik-Pharma, Russia
Shelf life | 3 years |
---|---|
Conditions of storage | In a dry, light-protected place at room temperature |
Manufacturer | Pik-Pharma, Russia |
Medication form | pills |
Brand | Pik-Pharma |
Other forms…
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