Diazolin, 100 mg tablets, 10 pcs.

Pharmacotherapeutic group: anti-allergic agent – H1-histamine receptor blocker.

ATC code: R06AX15

Pharmacological properties

Pharmacodynamics

H1-histamine receptor blocker. It has anti-allergic effect, reduces mucosal edema. It weakens the effect of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of the reduction of blood pressure and the increase in vascular permeability. Slightly penetrating into the central nervous system, unlike first generation antihistamines, it does not have a pronounced sedative and hypnotic effect. It has weak M-cholinoblocking and anesthetic properties.

Therapeutic effect occurs 15-30 minutes after intake, the maximum effect is observed after 1-2 hours. The duration of the effect may be up to 48 hours.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract (GIT), penetrates all body tissues, but practically does not penetrate through the blood-brain barrier. Bioavailability is 40-60%.

The drug is metabolized in the liver through methylation, induces microsomal liver enzymes and is excreted by the kidneys.

The elimination half-life (T_1/2) from plasma is about 4 hours.

Indications

Hay fever (hay fever), allergic conjunctivitis, urticaria, drug rash, skin reaction after an insect bite, allergic dermatoses accompanied by itchy skin.

Pharmacological effect

Pharmacotherapeutic group: antiallergic agent – H1-histamine receptor blocker.

ATX code: R06AX15

Pharmacological properties

Pharmacodynamics

H1-histamine receptor blocker. It has an antiallergic effect, reduces swelling of the mucous membranes. Weakens the effect of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of the decrease in blood pressure and increased vascular permeability. Penetrating slightly into the central nervous system, unlike first generation antihistamines, it does not have a pronounced sedative and hypnotic effect. It has mild M-anticholinergic and anesthetic properties.

The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 48 hours.

Pharmacokinetics

It is quickly absorbed from the gastrointestinal tract (GIT), penetrates all tissues of the body, but practically does not penetrate the blood-brain barrier. Bioavailability is 40-60%.

The drug is metabolized in the liver by methylation, induces microsomal liver enzymes, and is excreted by the kidneys.

The half-life (T1/2) from plasma is about 4 hours.

Special instructions

Impact on the ability to drive vehicles. Wed and fur.:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and high speed of psychomotor reactions.

Active ingredient

Mebhydrolin

Composition

Active ingredient:

mebhydroline napadisylate 100 mg;

Excipients:

sugar (sucrose);

starch syrup;

talc;

beeswax;

sunflower oil

Pregnancy

It is not recommended to take during pregnancy and lactation.

Contraindications

Hypersensitivity to the components of the drug, prostatic hyperplasia, angle-closure glaucoma, peptic ulcer of the stomach and duodenum, inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, heart rhythm disturbances, pregnancy, lactation, children under 3 years of age.

With caution

Hepatic and/or renal failure (dose adjustment and intervals between doses may be required.

Side Effects

From the digestive system: dyspepsia caused by the irritating effect of the drug on the mucous membrane of the gastrointestinal tract (heartburn, nausea, pain in the epigastric region).

Other: dry mouth, urinary retention, allergic reactions, extremely rarely – granulocytopenia and agranulocytosis.

From the nervous system: dizziness, paresthesia, tremor, increased fatigue, drowsiness, anxiety (at night), slowdown in the speed of psychomotor reactions.

Paradoxical reactions are possible in children: increased excitability, irritability, tremors, sleep disturbances.

Interaction

Enhances the effect of ethanol sedatives.

Overdose

There is no data on overdose.

Storage conditions

In a dry place, protected from light, at a temperature below 25 °C

Shelf life

3 years 6 months.
Do not use after the expiration date stated on the package.

Manufacturer

Pharmstandard-UfaVITA, Russia