Diara, capsules 2 mg 10 pcs

Diara is an anti-diarrheal agent.

Loperamide, by binding to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), reduces intestinal smooth muscle tone and motility (by inhibiting the release of acetylcholine and prostaglandins).

Slows down peristalsis and increases the time of passage of intestinal contents.

It increases tonicity of anal sphincter and helps in retention of feces and in reduction of urges to defecation. The action comes on quickly and lasts for 4-6 hours.

Indications

Active ingredient

Composition

Active ingredient:

loperamide hydrochloride 2.0 mg.

Auxiliary substances:

Magnesium stearate,

Corn starch,

Microcrystalline cellulose.

How to take, the dosage

Ingestion. In adults in acute and chronic diarrhea 2 capsules (4 mg) are taken in initial dose; then 1 capsule (2 mg) after each act of defecation (in case of liquid stools); maximum daily dose is 8 capsules (16 mg).

Children over 6 years of age in acute diarrhea are prescribed 1 capsule (2 mg) after each act of defecation in case of liquid stools; the maximum daily dose is 3 capsules (6 mg).

If there is no response within 48 hours, discontinue use and see a physician.

If stools are normalized or if stools are absent for more than 12 hours, treatment with Diara should be discontinued.

Special Instructions

If there is no effect within 48 hours, stop using the drug and see a doctor.

Contraindications

Hypersensitivity to the drug, diverticulosis, intestinal obstruction, acute ulcerative colitis, diarrhea against acute pseudomembranous enterocolitis, as monotherapy in dysentery and other gastrointestinal tract (GIT) infections; pregnancy (I trimester), lactation, children under 6 years.

With caution: liver failure.

Side effects

Gastralgia, dry mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation.

Extremely rare – intestinal obstruction.

Overdose

Symptoms: central nervous system (CNS) depression – stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertonia, respiratory depression; intestinal obstruction.

Treatment: the antidote is naloxone; given that the duration of action of loperamide is longer than that of naloxone, it is possible to reintroduce the latter.

Symptomatic treatment: activated charcoal, gastric lavage, artificial lung ventilation (ALV). Medical observation for at least 48 hours is necessary.

Similarities