Diabefarm CF, 30 mg 60 pcs
€3.67 €3.26
Diabetes mellitus type 2 Diabetes mellitus type 2 in combination with diet therapy and moderate physical activity when the latter is ineffective.
Active ingredient
Gliclazide
How to take, the dosage
The drug dose should be adjusted individually, depending on the clinical manifestations of the disease, glucose levels on an empty stomach and two hours after meals.
Usually the initial daily dose (including elderly people over 65 years of age) is 30 mg (1 tablet). The further dose is increased with an interval of at least 2 weeks, if necessary.
Maximal daily dose is 120 mg (4 tablets).
The preparation is taken orally once a day in the morning during breakfast.
Diabefarm®MV can substitute Diabefarm in doses from 1 to 4 tablets per day.
It can be used in combination with other hypoglycemic agents: biguanides, alpha-glucosidase inhibitors or insulin.
Patients with renal function disorders of mild to moderate severity (creatinine clearance from 15 to 80 ml/min) are prescribed the drug in the same dosage.
Interaction
Angiotensin-converting enzyme inhibitors (captopril, enalapril), H2-histamine receptor blockers (cimetidine), antifungal drugs (miconazole, fluconazole) enhance the hypoglycemic effect of Diabefarm®MV, nonsteroidal anti-inflammatory drugs (phenylbutazone, indomethacin, diclofenac, azapropazon, oxyphenbutazone), tetracycline, fibrates (clofibrate, besafibrate), anti-tuberculosis drugs (etionamide), salicylates Coumarin-type indirect anticoagulants, anabolic steroids, beta-adrenoblockers, cyclophosphamide, chloramphenicol, monoamine oxidase inhibitors, prolonged sulfonamides, phenfluramine, fluoxetine, pentoxifylline, guanethidine, theophylline, drugs that block tubular secretion, reserpine, bromocriptine, disopyramide, pyridoxine, allopurinol, ethanol and ethanol-containing drugs, and other hypoglycemic drugs (acarbose, biguanides, insulin).
The hypoglycemic effect of Diabefarm®MV is weakened by barbiturates, glucocorticosteroids, sympathomimetics (epinephrine, clonidine, ritodrine, salbutamol, terbutaline), phenytoin, “slow” calcium channel blockers, carboangidrase inhibitors (acetazolamide), thiazide diuretics, Chlorthalidone, furosemide, triamtaren, asparaginase, baclofen, danazol, diazoxide, isoniazid, morphine, glucagon, rifampicin, thyroid hormones, lithium salts, in high doses – nicotinic acid, chlorpromazine, estrogens and oral contraceptives containing them.
In interaction with ethanol a disulfiram-like reaction may occur.
Gliclazide increases the risk of ventricular extrasystole in cardiac glycosides.Beta-adrenoblockers, clonidine, reserpine, guanethidine may mask clinical manifestations of hypoglycemia.
Simultaneous use with drugs that suppress medullary hematopoiesis increases the risk of myelosuppression.
Special Instructions
Treatment with Diabefarm®MB is carried out in combination with a low-calorie low-carbohydrate diet.
Blood glucose content should be regularly monitored on an empty stomach and after meals. In case of surgical interventions or decompensation of diabetes it is necessary to consider the possibility of using insulin drugs.
Patients should be warned about the increased risk of hypoglycemia in cases of ethanol, nonsteroidal anti-inflammatory drugs and starvation. If ethanol is taken, a disulfiram-like syndrome (abdominal pain, nausea, vomiting, headache) may also develop.
The drug dose should be corrected in case of physical or emotional stress, changes in diet. The hypoglycemic agents are especially sensitive to the action of elderly patients, patients with unbalanced diet, weakened patients, patients with pituitary-adrenal insufficiency.
At the beginning of treatment and during dose adjustment it is not recommended for patients prone to hypoglycemia to engage in activities requiring increased attention and rapid psychomotor reactions.
Side effects
Hypoglycemia (in case of violation of the dosing regime and inadequate diet): headache, fatigue, hunger, sweating, sudden weakness, aggressiveness, anxiety, irritability, inattention, inability to concentrate and slow reaction, depression, visual disturbances, aphasia, tremor, feeling of helplessness, sensory disorders, dizziness, loss of self-control, delirium, seizures, hypersomnia, loss of consciousness, shallow breathing, bradycardia.
Digestive system disorders: dyspepsia (nausea, diarrhea, feeling of heaviness in epigastrium); anorexia – reduced severity with meals, liver disorders (cholestatic jaundice, increased liver transaminase activity).
Blood disorders: anemia, thrombocytopenia, leukopenia.
Allergic reactions: itching, urticaria, maculopapular rash.
Overdose
In overdose, hypoglycemia is possible, up to the development of a hypoglycemic coma.
Pregnancy use
It is contraindicated in pregnancy. Breastfeeding should be stopped during treatment.
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Similarities
Diabeton MB, Glidiab, Gliclazide MB, Diabetalong, Gliclazide Canon, Gliclazide, Golda MB
Weight | 0.040 kg |
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Shelf life | 3 years |
Conditions of storage | In a dry, light-protected place at a temperature not exceeding 25 °C |
Manufacturer | Pharmacor Production, Russia |
Medication form | controlled release tablets |
Brand | Pharmacor Production |
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