Devirs, cream 7.5% 15 g

Name: Devirs, cream 7.5% 15 g
SKU: 213920
Availability: InStock

€16.38

EAN: 4607003244170 SKU: 213920 Categories: Antiviral, Medicine

Description

Pharmgroup:

Antiviral drug for external use

Pharmic action:

Devirs is an antiviral drug.

Ribavirin triphosphate (RTF) is a potent inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase), viral RNA polymerase and viral mRNA guanylyltransferase. Inhibition of the latter stops mRNA capping, resulting in significant depletion of intracellular guanosine triphosphate stores and inhibition of viral RNA and protein synthesis. Ribavirin also integrates into the viral genome, causing lethal mutations, with a subsequent reduction in the pathogenicity of the virus.

Ribavirin inhibits replication of new virions, which ensures reduction of viral load, selectively inhibits viral RNA synthesis without suppressing RNA synthesis in normally functioning cells.

The most sensitive DNA viruses to ribavirin are herpes simplex virus, adenoviruses, CMV, smallpox group viruses, Marek’s disease; RNA viruses – influenza A, B, paramyxoviruses (parainfluenza, mumps, Newcastle disease), reoviruses, arenaviruses (Lassa fever virus, Bolivian hemorrhagic fever virus), bunyaviruses (Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus), hantaviruses (hemorrhagic fever virus with renal or pulmonary syndrome), oncogenic RNA viruses.

Ribavirin-insensitive DNA viruses: Varicella zoster, pseudorabies virus, natural cowpox; RNA viruses: enteroviruses, rhinoviruses, Semliki forest encephalitis virus.

Pharmacokinetics:

When applied to the skin and topically, systemic absorption is minimal and virtually insignificant.

Indications
Indications
Herpes
As monotherapy or in combination with oral and parenteral ribavirin dosage forms for the following diseases:
– Skin and mucous membrane infections caused by Herpes simplex viruses of types 1 and 2, with different localizations, including in the genital area;
– Herpes zoster (as part of complex therapy).

Active ingredient
Active ingredient
Ribavirin

Composition
Composition
Active ingredient:
Ribavirin 7.5 g.
Excipients:
glyceryl monostearate (glycerol monostearate 40-45) – 2.0 g,
macrogoal 6 cetoasteryl alcohol ester (macrogoal 6 cetoasteryl ester) – 1.5 g, macrogoal 25 cetoasteryl alcohol ester (macrogoal 25 cetoasteryl ester) – 1.5 g,
cetoasteryl alcohol – 5.0 g, <
liquid paraffin (Vaseline oil) – 5,0 g,
methylparahydroxybenzoate (methylhydroxybenzoate, methylparaben, nipagin) – 0,1 g,
propylparahydroxybenzoate (propyl hydroxybenzoate, propylparaben, nipazole) – 0.02 g,
purified water – up to 100.0 g.

How to take, the dosage
How to take, the dosage
Outwardly, apply to the affected areas of the skin and mucous membranes (previously washed and dried) evenly thin layer, lightly rubbing.
Apply 5 times a day until the complete disappearance of symptoms.
If there is no improvement within 8 days of using the drug, stop taking and consult a doctor.
For best effect the treatment should be started as soon as possible after the first symptoms.
If Devirs cream? is used in combination with oral or intravenous ribavirin, the dose should be reduced.

Special Instructions
Special Instructions
Do not use to treat ophthalmoherpes, do not apply in the eye area.
The drug should be used with extreme caution in patients with renal insufficiency.
Men and women of childbearing age should use effective contraceptives during treatment and for 7 months after therapy.
.

Contraindications
Contraindications
– pregnancy;
– lactation period (breastfeeding);
– children and adolescents under 18 years of age;
– hypersensitivity to the components of the drug Devirs.
With caution. The preparation should be used Devirspri renal insufficiency, in men and women of reproductive age.
.

Side effects
Side effects
Allergic reactions (skin rash, urticaria, exanthema) are possible.
Other: hair loss, changes in thyroid hormone (TSH), symptoms of autoimmune diseases (very rare).
Observed effects are usually reversible, do not affect the effectiveness of treatment and disappear after treatment completion.
.

Similarities
Similarities
Ribavirin

Additional information
Weight 0.022 kg
Shelf life
2 years
Conditions of storage
In a dry place, at a temperature not exceeding 25 °C
Manufacturer
Vertex, Russia
Medication form
exterior cream
Brand
Vertex