Delagil, tablets 250 mg, 30 pcs.

An antiprotozoal agent, it also has immunosuppressive and anti-inflammatory effects.

Delagil causes death of asexual erythrocytic forms of all types of plasmodia.

It has gametocidal action, except for Plasmodium falciparum (shows antigametocidal action).

Indications

– malaria (prevention and treatment of all types);
– extraintestinal amoebiasis;
– amebic liver abscess;
– Systemic lupus erythematosus (chronic and subacute forms);
– Rheumatoid arthritis;
– Scleroderma;
– Photodermatosis.

Active ingredient

Composition

1 tablet contains chloroquine 250 mg

How to take, the dosage

Delagil is taken orally, after meals.
In the treatment of malaria, 2-2.75 g is prescribed per course of treatment: 1 g/the first day, after 11-12 hours 0.5 g, on the second and third days – 0.5-0.75 g at a time. Maximum dosage for adults is 1.5 g at a time. Children 6-10 years old are prescribed 0.25 g during the first day, then 0.125 g during the second and third days of treatment. Children of 10-15 years old – 0.5 g during the first day and then 0.25 g during the second and third day.
Prophylaxis of malaria infection: 0.5 g twice a week and then 0.5 g once a week. In case of rheumatoid arthritis, Delagil is taken 0.5 g/day in two doses for 6-8 days. Then 0.25 g daily for 12 months.

Interaction

Co-administration of other antimalarial drugs increases the effect of Delagilus.

Do not take together with drugs of gold, cytostatics, penicillamine, levamisole, because it may increase the side effects of the drug.

When co-administration with MAO inhibitors there is an increase in the toxic effect.

Long-term use of Delagil together with cardiac glycosides may lead to glycoside intoxication.

Ethanol increases the toxic effect of Delagil on the liver.

Contraindications

– malaria (prevention and treatment of all types);
– extraintestinal amoebiasis;
– amebic liver abscess;
– Systemic lupus erythematosus (chronic and subacute forms);
– Rheumatoid arthritis;
– Scleroderma;
– Photodermatosis.

Side effects

– Nervous system disorders: dizziness, psychomotor agitation, headache, insomnia, psychosis, neuropathies, seizures.

– Musculoskeletal system: myopathies.

– Sensory analyzers: hearing impairment, tinnitus, impaired vision, corneal clouding, retinopathy, accommodation disorders, reversible keratopathy.

– Digestive system disorders: nausea, vomiting, diarrhea, anorexia, abdominal pain of spastic character, weight loss, hepatotoxicity.

– Vascular system disorders: possible development of arterial hypotension and cardiomyopathy.

– Skin manifestations: dermatitis, skin itching, rash, photosensitization, skin pigmentation disorders, hair loss.

Overdose

In case of overdose of this drug loss of consciousness, vomiting, respiratory depression, seizures, collapse are observed.

In case of overdose it is necessary to flush the stomach, take oral adsorbents.

In severe cases of poisoning it is possible to use plasmapheresis and peritoneal dialysis.