Cytoflavin, 100 pcs

Pharmacodynamics

Pharmacological effects are caused by the complex action of the constituent components of CITOFLAVIN®.
CITOFLAVIN® promotes activation of aerobic metabolism of cells resulting in increase of glucose utilization, promotes increased level of beta-oxidation of fatty acids and resynthesis of γ-aminobutyric acid in neurons.

CITOFLAVIN® increases resistance of nerve and glial cell membranes to ischemia, which is manifested by a decrease in the concentration of neuro-specific proteins that characterize the level of destruction of the main structural components of nervous tissue.
CITOFLAVIN® improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores disturbed consciousness, facilitates regress of neurological symptoms and improves brain cognitive functions. It has a fast awakening effect in post-arrest depression of consciousness.

When administering CITOFLAVIN® within the first 12 hours of the onset of stroke a favorable course of ischemic and necrotic processes in the affected area (decrease of the focus), recovery of neurological status and decrease of disability level in the long-term period are observed.

Pharmacokinetics

Cytoflavin has high bioavailability.

Amber acid when taken orally penetrates from the gastrointestinal tract into the blood and tissues, participating in reactions of energy metabolism, and is completely broken down to the end products of metabolism (carbon dioxide and water) in 30 minutes.

Inosine is well absorbed from the gastrointestinal tract. Time of reaching maximum concentration in blood is 5 hours, average time of retention in blood is 5.5 hours, equilibrium volume of distribution is about 20 liters. Inosine is metabolized in the liver to form inosine monophosphate with its subsequent oxidation to uric acid. Insignificant amount is excreted by the kidneys.

Nicotinamide is rapidly distributed in all tissues (equilibrium volume of distribution is about 500 liters). Time of reaching maximum concentration in blood is 2 hours, average time of retention in blood is 4.5 hours. Nicotinamide penetrates through the placenta and into the breast milk, is metabolized in the liver to form N-methylnicotinamide, excreted by the kidneys.

Riboflavin is rapidly absorbed from the gastrointestinal tract, distributed unevenly (the greatest amount in the myocardium, liver and kidneys), is transformed into flavinadenine mononucleotide (FMN) and flavinadenine dinucleotide (FAD) in mitochondria. Passes through the placenta and into breast milk; excreted by the kidneys, mainly as metabolites.

Indications

Stroke Consequences, Atherosclerosis, Cerebral Circulatory Disorders, Headache

In adults in the complex therapy:
1. Acute stroke.
2. Consequences of cerebrovascular diseases (consequences of brain infarction, cerebral atherosclerosis).
3. Toxic and hypoxic encephalopathy in acute and chronic poisonings, endotoxicosis, post-arrest depression of consciousness as well as for prevention and treatment of hypoxic encephalopathy during cardiac surgery using artificial circulation.

In children (including prematurely born with gestation period of 28-36 weeks) during the period of neonatal:
1. In cerebral ischemia.

Active ingredient

Inosine, Nicotinamide, Riboflavin, Amber acid

Composition

1 tablet contains:

the active ingredients:

succinic acid – 0.3 g;

riboxin (inosine) – 0.05 g;

nicotinamide – 0.025 g;

riboflavin mononucleotide (riboflavin) – 0.005 g;

excipients:

polyvinylpyrrolidone medium molecular weight (povidone),

calcium stearate,

copolymer of methacrylic acid and ethyl acrylate,

1,2-propylene glycol,

acid red 2C,

Tropeolin O.

How to take, the dosage

In the oral intake of 2 tablets 2 times a day with an interval between doses of 8-10 hours. Tablets should be taken at least 30 minutes before a meal, without chewing, with water (100 ml).

It is recommended to take the drug in the morning and in the afternoon (not later than 18 hours).

The course of treatment lasts 25 days. Appointment of a repeated course is possible with an interval of at least 1 month.

Interaction

Amber acid, inosine and nicotinamide are compatible with other drugs.

Riboflavin reduces the activity of some antibiotics (tetracyclines, erythromycin, lincomycin), incompatible with streptomycin.

Ethanol, tricyclic antidepressants, blockers of tubular secretion reduce the absorption of riboflavin, and thyroid hormones accelerate its metabolism.

Special Instructions

In hypertensive patients, doses of hypotensive drugs may need to be adjusted.

In diabetic patients, treatment should be carried out under control of blood glucose concentration.

It is possible intensive staining of urine yellow.

CITOFLAVIN has no effect on: the ability to drive vehicles, work with moving machinery, the work of controllers and operators.

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Contraindications

Hypersensitivity, patients undergoing ventilatory ventilation, when the partial pressure of oxygen in the arterial blood is less than 60 mm Hg, the period of breast-feeding.

With caution – nephrolithiasis, gout, hyperuricemia.

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Side effects

Headache, pain or discomfort in the epigastric region.

Allergic reactions in the form of skin hyperemia and itching are possible. Adverse reactions include: transient hypoglycemia, hyperuricemia, exacerbation of concomitant gout.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

To date, no cases of overdose with CITOFLAVIN have been established.