Cromohexal, spray 2.8mg/dose 15 ml

Pharmgroup:

anti-allergic agent – stabilizer of mast cell membranes.

Pharmic action:

CromoHexal is a peroallergic, anti-inflammatory drug.

Stabilizer of mast cell membranes. It blocks the entrance of ions into the mast cell, preventing its degranulation and the release of allergy and inflammation mediators (histamine, bradykinin, prostaglandins, leukotrienes and other biologically active substances).

Prevent manifestation of allergic reactions of immediate type.

Pharmacokinetics:

Absorption through the mucous membrane of the eye is negligible. Systemic bioavailability is less than 0.03%. T1/2 is 5-10 minutes.

Indications

Prevention and treatment of acute and chronic allergic keratoconjunctivitis (pollinosis, spring keratoconjunctivitis).

Active ingredient

Composition

Active ingredient:

Dinatrium salt of cromoglycic acid.

Other constituents:

benzalkonium chloride,

EDTA,

sodium chloride,

sodium dihydrophosphate,

sodium monohydrophosphate,

sorbitol,

water for injection.

How to take, the dosage

Intranasally, adults and children: 1 dose in each nostril 4 times a day (up to 6 times a day, if necessary).

Special Instructions

In addition to the above adverse reactions, the following have been described for inhaled cromoglycic acid (cause-effect relationship not proven): 1 in 10,000 patients with angioedema, bronchospasm, cough, dizziness, dysuria (including frequent urination), headache, arthralgia, swelling of the joints, laryngeal edema, lacrimation, nausea, rash, urticaria, and dysuria.

Headache, arthralgia, joint swelling, laryngeal edema, lacrimation, nausea, nasal congestion, rash, parotid salivary gland swelling, urticaria.

In 1 out of 100 thousand patients anemia, exfoliative dermatitis, hemoptysis, hoarseness of voice, myalgia, nephropathy, periarteritis, pericarditis, peripheral neuritis, photodermatitis, polymyositis, pulmonary infiltrates with eosinophilia have been reported. There have been no reports of similar effects when using forms for intranasal administration.

The therapy should be continued for the duration of allergen action.

If irritation or burning of the nasal mucosa persists or increases, treatment must be discontinued.

Contraindications

– hypersensitivity to cromoglycic acid or other constituents of the drug CromoGexal.

Side effects

Possible: rarely – mild irritation in the nose; very rare – headache, temporary violation of the sense of taste; in single cases – nasal bleeding, nasal mucous membrane irritation, swelling of the tongue, larynx, hoarseness, severe generalized anaphylactic reactions with bronchospasm, cough and choking.

The patient should consult a physician if there are significant side effects, and if there are any complaints not listed above.

Similarities