Corvalol, tablets 20 pcs
€5.11 €4.54
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Pharmacological action:
Corvalol is a combined preparation, the action of which is due to the properties of its constituent substances. It has sedative and antispasmodic effect. It facilitates the onset of natural sleep.
. Ethyl ester of alpha-bromisovaleric acid has sedative (similar to the effect of valerian) and antispasmodic action, which is caused mainly by irritation of the receptors in the mouth and nasopharynx, Decrease of reflex excitability in central parts of nervous system and increased inhibition in neurons of cerebral cortex and subcortical structures, as well as decreased activity of central vasomotor centers and direct local antispasmodic action on smooth muscles.
Phenobarbital increases the sedative effect of the other components, reduces CNS agitation and facilitates sleep.
Peppermint oil has a reflex vasodilatory, antispasmodic, mild choleretic, antiseptic action.
The mechanism of action is associated with the ability to irritate the “cold” receptors of the mucous membrane of the mouth, and reflexively dilate the heart and brain vessels. It eliminates the phenomena of flatulence due to irritation of the mucous membrane receptors of the gastrointestinal tract, increasing the intestinal peristalsis.
Indications
Corvalol is prescribed as a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system, neurosis-like conditions accompanied by increased irritability, difficulty falling asleep, tachycardia, a state of agitation with pronounced vegetative manifestations;
as an antispasmodic – for intestinal spasms.
Pharmacological effect
Pharmaceutical action:
Corvalol is a combination drug, the effect of which is determined by the properties of the substances included in its composition. Has a sedative and antispasmodic effect. Facilitates the onset of natural sleep.
Ethyl ester of alpha-bromoisovaleric acid has a sedative (similar to the effect of valerian) and antispasmodic effect, which is caused by irritation mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscles.
Phenobarbital enhances the sedative effect of other components, helps reduce central nervous system excitation and facilitates the onset of sleep.
Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect.
The mechanism of action is associated with the ability to irritate the “cold” receptors of the oral mucosa and reflexively dilate mainly the vessels of the heart and brain. Eliminates flatulence by irritating receptors in the gastrointestinal mucosa, enhancing intestinal motility.
Special instructions
There is no experience with the use of the drug in children under 18 years of age.
You should not drink alcohol while using Corvalol.
It is recommended to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles and working with complex mechanisms).
Active ingredient
Phenobarbital, Alpha-bromoisovaleric acid ethyl ester, Sodium hydroxide, Peppermint oil
Composition
1 tab.:
– peppermint oil 580 mcg
– phenobarbital 7.5 mg
– α-bromoisovaleric acid ethyl ester 8.2 mg
Excipients:
beta-cyclodextrin 55.55 mg,
potato starch 13 mg,
lactose monohydrate 43.77 mg,
microcrystalline cellulose 10.5 mg,
magnesium stearate 0.9 mg.
Contraindications
Hypersensitivity to the components of the drug Corvalol;
severe renal and/or liver dysfunction,
lactation period (if it is necessary to use during breastfeeding, the issue of stopping breastfeeding should be decided),
pregnancy,
age up to 18 years (efficacy and safety have not been established),
lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the drug contains lactose).
Side Effects
Drowsiness, dizziness, slow heart rate, decreased ability to concentrate, allergic reactions. Gastrointestinal disturbances may occur. These phenomena disappear when the dose of Corvalol is reduced or the drug is stopped.
With prolonged use of the drug, drug dependence, addiction, “withdrawal” syndrome, as well as the accumulation of bromine in the body and the development of bromism phenomena may occur.
Interaction
Medicines that depress the central nervous system enhance the effect of Corvalol.
Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the effect of local anesthetics, analgesics and hypnotics. The drug increases the toxicity of methotrexate.
The effect of the drug is enhanced by the use of valproic acid drugs.
Overdose
Symptoms: central nervous system depression, nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment: discontinuation of the drug, gastric lavage and symptomatic therapy; in case of central nervous system depression – caffeine, niketamide.
Manufacturer
Pharmstandard-Leksredstva, Russia
Manufacturer | Pharmstandard-Leksredstva, Russia |
---|---|
Medication form | pills |
Brand | Pharmstandard-Leksredstva |
Other forms…
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