Corvalol Fito, drops 50 ml

Sedative

Pharmacodynamics

A combined drug, the action of which is caused by the properties of its constituent substances. It has sedative and antispasmodic effects, moderate cardiotonic effect (slows the rhythm and increases the force of the heart beats), and has moderate hypotensive properties.

Ethylbromisovalerianat has sedative and antispasmodic effect caused by irritation, mainly of receptors in the oral cavity and nasopharynx, reduction of reflex excitability in central nervous system and increased inhibition in cortical and subcortical structures of the brain, also by decrease of activity of central vasomotor centers and direct local spasmolytic effect on smooth muscles.

The motherwort herb has a pronounced sedative (sedative), moderate cardiotonic (slows rhythm and increases the force of heart contractions), moderate hypotensive action.

Pearmint oil has reflex vasodilatory, antispasmodic, mild choleretic, antiseptic action. The mechanism of action is related to the ability to irritate the “cold” receptors of the oral mucosa and reflexively dilate mainly vessels of the heart and brain. It eliminates the phenomena of flatulence by irritating the mucosal receptors of the gastrointestinal tract (GIT), increasing intestinal peristalsis.

Pharmacokinetics

There are no data on the pharmacokinetics of ethylbromisovalerianate, motherwort and peppermint components.

Indications

Sleep disorders, neurosis-like conditions accompanied by increased irritability and excitability, states of agitation with marked autonomic manifestations;

As an antispasmodic agent – in intestinal spasms, and as a symptomatic (sedative and vasodilator) means in functional disorders of the cardiovascular system.

Composition

Ingredients per 1 ml:

Active ingredients: motherwort herb tincture – 720.00 mg; ethylbromisovalerianate – 20.00 mg; peppermint leaf oil (peppermint oil) -1.42 mg.

Excipients: Purified water – up to 1 ml.

To obtain 100 ml of motherwort tincture 20 g of motherwort herb and a sufficient amount of ethyl alcohol 70% are used.

How to take, the dosage

Adults

Take orally, before meals, 3 times a day, 30 drops dissolved in a small amount (30-40 ml) of water.

The course of treatment is 4 weeks (28 days). The duration of intake can be increased by the doctor’s recommendation.

Interaction

When concomitant use of the drug Corvalol Fito with drugs depressing the central nervous system (sedatives, hypnotics, neuroleptics, tranquilizers) mutual enhancement of effects is possible. Increases the effect of antispasmodics, analgesics. Alcohol increases the effect of the drug and its toxicity.

Special Instructions

There is no experience of using the drug in children under 18 years of age, during pregnancy and breast-feeding. Long-term use of the drug in high doses is not recommended due to possible toxic effect of bromine cumulation in the body. During the use of the drug it is not recommended to drink alcohol.

Corvalol Fito contains 47,5% of ethyl alcohol; therefore, if administered orally, its maximum single dose contains 0.308 g of absolute ethanol (ethanol), and in maximum daily dose – 0.923 g.

Impact on driving and operating machinery

Patients are advised to refrain from driving and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor and motor reactions during treatment due to possible dizziness, reduced concentration and other adverse effects associated with the drug.

Synopsis

Clear greenish-brown liquid with a characteristic odor. Suspension of small particles is allowed. During storage sludge formation is allowed

Contraindications

– hypersensitivity to the components of the drug;

– severe renal and/or hepatic function disorders;

– erosive-ulcerative lesions of the gastrointestinal tract (acute phase);

– pregnancy;

– period of breastfeeding;

– children under 18 years of age (efficacy and safety are not established).

With caution

– Impaired liver and/or kidney function;

– Epilepsy;

– Alcoholism;

p> – High-risk patients, including those with liver disease, traumatic brain injury, and brain disease.

Side effects

Immune system disorders: allergic reactions;

Central nervous system disorders: drowsiness, weakness, dizziness, decreased ability to concentrate;

Cardiovascular system: slowing of heart rate;

Gastrointestinal tract: dyspepsia.

The above phenomena disappear with reduction of the drug dose or discontinuation of the drug. When prolonged use of high doses of the drug it is possible to develop drug addiction as well as bromine accumulation in the body and development of bromism which manifestation are: depressed mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, movement coordination disorders.

Overdose

Overdose is possible with frequent and prolonged use of the drug. If the recommended doses are exceeded, dose-dependent side effects may increase.

Symptoms: weakness, drowsiness, dizziness. Chronic bromine intoxication may occur with prolonged use (See side effects).

Treatment: symptomatic.

Pregnancy use

Safety of Corvalol Fito during pregnancy has not been established and its use during this period is contraindicated. There is no data on penetration of the drug components into the breast milk, so if it is necessary to use during breast-feeding, the question of stopping breast-feeding should be solved.