Cortexin, lyophilizate 10 mg 22 g 10 pcs

CORTEXIN contains a complex of low molecular weight water-soluble polypeptide fractions penetrating directly through the blood-brain barrier to the nerve cells. The product has nootropic, neuroprotective, antioxidant and tissue-specific effects. It improves higher brain functions, learning and memory processes, concentration of attention, resistance to various stress influences.

Neuroprotective – protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant – inhibits lipid peroxidation in neurons, increases the survival of neurons in conditions of oxidative stress and hypoxia. Tissue-specific – activates the metabolism of central and peripheral nervous system neurons, repair processes, improves cortical functions and overall tonus of the nervous system.

Mechanism of action

CORTEXIN is due to activation of neuronal peptides and neurotrophic factors of the brain; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABAergic action; reduction of paroxysmal seizure activity of the brain, ability to improve its bioelectrical activity; prevention of free radical formation (products of lipid peroxidation).

Pharmacokinetics

The composition of CORTEXIN, whose active substance is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.

Indications

In the complex treatment of cerebral circulatory disorders, traumatic brain injury and its consequences, encephalopathies of various origins, cognitive impairment (memory and thinking disorders), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic conditions (suprasegmental autonomic disorders), reduced learning ability, delayed psychomotor and speech development in children, various forms of childhood cerebral paralysis.

Pharmacological effect

Pharmacotherapeutic group: nootropic agent.

ATX code: N06BX.

Characteristic

Cortexin is a complex of water-soluble polypeptide fractions with a molecular weight of no more than 10,000 Da.

Pharmacological action

Pharmacodynamics

CORTEXIN contains a complex of low molecular weight water-soluble polypeptide fractions that penetrate the blood-brain barrier directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.

Nootropic – improves higher brain functions, learning and memory processes, concentration, and resistance to various stressors.

Neuroprotective – protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Antioxidant – inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.

Tissue-specific – activates the metabolism of neurons in the central and peripheral nervous system, reparative processes, helps improve the functions of the cerebral cortex and the general tone of the nervous system.

The mechanism of action of the drug CORTEXIN is due to the activation of neuronal peptides and neurotrophic factors of the brain; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABAergic effects; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectrical activity; preventing the formation of free radicals (products of lipid peroxidation).

Pharmacokinetics

The composition of the drug CORTEXIN, the active substance of which is a complex of polypeptide fractions, does not allow for conventional pharmacokinetic analysis of individual components.

Special instructions

Use CORTEXIN® only as prescribed by your doctor!

When using a 0.5% solution of procaine (novocaine) as a solvent for the drug CORTEXIN®, you should adhere to the information on contraindications, precautions and age restrictions set out in the instructions for use of procaine (novocaine).
The use of the local anesthetic Lidocaine as a solvent for preparing a solution of the drug CORTEXIN® is not recommended.
The bottle with the dissolved medicinal product must not be stored or used after storage. The CORTEXIN® solution is not recommended to be mixed with other solutions.
There are no specific effects of the drug upon first use or upon discontinuation.
If an injection is missed, it is not recommended to administer a double dose, but to administer the next injection as usual on the scheduled day.
No special precautions are required when disposing of unused medications.

Impact on the ability to drive vehicles and machinery
If symptoms of stimulant action occur (see section “Side Effects”), the drug may affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, working with moving mechanisms).

Active ingredient

Livestock cerebral cortex polypeptides

Composition

One bottle contains:

active ingredient – ​​Cortexin 10 mg (complex of water-soluble polypeptide

factions),

excipient – ​​glycine 12 mg (stabilizer).

Pregnancy

The drug is contraindicated during pregnancy (due to the lack of clinical trial data). If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of clinical trial data).

Contraindications

Individual intolerance to the drug.

Side Effects

The following adverse reactions observed during clinical use are listed below according to systemic organ classification, in descending order of occurrence: very common (≥1/10), common (≥1/100, but <1/10), uncommon (≥1/1,000, but <1/100), rare (≥1/10,000, but <1/1,000), very rare (<1/10,000).

Immune system disorders:

Anaphylactic shock, angioedema, larynx, skin rash, itching, skin hyperemia

General disorders and disorders at the injection site:

Hyperemia at the injection site

Nervous system disorders:

Psychomotor agitation, loss of coordination, movements, insomnia

Cardiac disorders:

Tachycardia (increased heart rate)

Mental disorders:

Feeling anxious

Interaction

The use of the local anesthetic lidocaine as a solvent for preparing a solution in children is associated with an increase in the severity of adverse reactions, and therefore its use is not recommended. (See “Special Instructions”)

Overdose

Currently, no cases of drug overdose have been reported.

Storage conditions

In a place protected from light at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after the expiration date indicated on the package.

Manufacturer

Geropharm LLC, Russia