Cordiamine, 250 mg/ml 2 ml pcs

Pharmacotherapeutic group: Analeptics.

To be sure to take the medicine.

Pharmacological action.

Pharmacodynamics.

The analeptic agent of mixed action. Mechanism of action consists of central and peripheral effects on the nervous system. The central mechanism is related to direct effect on vasomotor center of medulla oblongata, resulting in its excitation and mediated increase in blood pressure (especially if this center is initially inhibited). Peripheral effect is caused by excitation of carotid sinus chemoreceptors, which leads to increased frequency and depth of respiratory movements. There is no direct effect on the cardiovascular system.

Pharmacokinetics.

The absorption is high and does not depend on the route of administration. It is rapidly metabolized in the liver to form inactive metabolites, which are eliminated mainly by the kidneys.

Indications

Collapse, asphyxia (including newborns), shock during surgical operations and in the postoperative period, respiratory and circulatory depression in infectious diseases.

Pharmacological effect

Pharmacotherapeutic group: Analeptic drug.

ATX code: R07AB02.

Pharmacological action.

Pharmacodynamics.

Mixed action analeptic. The mechanism of action consists of central and peripheral effects on the nervous system. The central mechanism is associated with a direct effect on the vasomotor center of the medulla oblongata, leading to its excitation and an indirect increase in blood pressure (especially when this center is initially depressed). The peripheral effect is due to the stimulation of the chemoreceptors of the carotid sinus, which leads to an increase in the frequency and depth of respiratory movements. Does not have a direct effect on the cardiovascular system.

Pharmacokinetics.

Absorption is high and does not depend on the route of administration. Subject to rapid metabolism in the liver with the formation of inactive metabolites, excreted mainly by the kidneys.

Active ingredient

Niketamide

Composition

1 ml of the drug contains:

active ingredient – niketamide 250.0 mg;

excipient – water for injection up to 1.0 ml.

Pregnancy

There is no reliable data on the safety of using the drug during pregnancy and lactation.

It is not recommended to use this drug during pregnancy and breastfeeding.

Contraindications

Hypersensitivity to the components of the drug;

Decreased seizure threshold, seizures (including history);

Hyperthermia in children;

Pregnancy, lactation period.

Side Effects

From the digestive system: vomiting.

From the nervous system: anxiety, muscle contractions (starting from the orbicularis oris muscles).

From the skin: itching, facial flushing.

From the cardiovascular system: arrhythmia.

Other: pain at the injection site, allergic reactions.

Interaction

Enhances the effects of psychostimulants and antidepressants.

Reduces the effect of narcotic analgesics, hypnotics, antipsychotic and antiepileptic drugs, anxiolytics.

Reduces the effectiveness of niketamide: aminosalicylic acid, opiniazid, phenothiazine derivatives and drugs for general anesthesia. The convulsive effect of the drug is enhanced by reserpine and aminazine.

The pressor effect of niketamide is enhanced by monoamine oxidase inhibitors.

Overdose

Symptoms of overdose: increased severity of dose-dependent side effects, generalized tonic-clonic convulsions.

Measures to assist in case of overdose: symptomatic treatment (including anticonvulsants).

Storage conditions

Store in a place protected from light at a temperature not exceeding 25 ° C, out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Manufacturer

Kursk biofactory-firm Biok, Russia