Coldrex Junior Hot Drink, 10 pcs.

Combined drug for symptomatic treatment of acute respiratory diseases.

Paracetamol has antipyretic and analgesic effect.

Phenylephrine hydrochloride is a sympathomimetic, narrows the blood vessels of the nasal mucosa and paranasal sinuses, which reduces swelling and facilitates nasal breathing.

Ascorbic acid replenishes the increased need for vitamin C in colds and flu.

Indications

Headache, Sore throat, Colds, Flu, runny nose (rhinitis) For treating symptoms of acute respiratory infections and flu in children 6-12 years old, including.Fever
– headache
– chills
– joint and muscle pain
– a stuffy nose
– pain in the sinuses and throat.

Active ingredient

Paracetamol, phenylephrine, ascorbic acid

Composition

Paracetamol 300 mg,

Phenylephrine hydrochloride 5 mg,

Ascorbic acid 20 mg.

Auxiliary substances:

sodium saccharinate,

sodium cyclamate,

citric acid,

sodium citrate,

corn starch,

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sucrose,

lemon flavoring (610399E),

curcumin dye (E100),

silicon dioxide colloid.

How to take, the dosage

For oral administration.
Do not exceed the specified dose!

The smallest dose necessary to achieve the effect in the shortest possible period of treatment should be used!
The minimum interval between doses of the drug Coldrex Junior should be at least 4 hours.

Pour the contents of 1 sachet in a mug, pour approximately 125 ml of hot water, stir until dissolved. If necessary, add cold water and sugar.

Children from 6 to 12 years: 1 sachet every 4 – 6 hours, but no more than 4 sachets per day. The maximum daily dose should not exceed 4 bags. The maximum duration of the drug without consulting the physician is 3 days.

Do not take simultaneously with other paracetamol-containing agents, decongestants and agents to relieve symptoms of colds and flu, as well as with ethanol-containing drugs and beverages.

If the drug while taking the symptoms persist, it is necessary to consult a physician.

Interaction

Paracetamol when taken for a long time increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Episodic administration of a single dose of the drug has no significant effect on the effect of indirect anticoagulants.

Inducers of enzymes of microsomal oxidation in the liver (barbiturates, diphenine, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effect in overdose and in concurrent use with paracetamol.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.

Paracetamol reduces the effectiveness of diuretics.

Metoclopramide and domperidone increase, and colestyramine reduces the rate of absorption of paracetamol.

Paracetamol increases the effects of MAO inhibitors, sedatives, ethanol.

Phenylephrine when taken with MAO inhibitors may lead to increased BP.

Phenylephrine reduces the effectiveness of beta-adrenal blockers and antihypertensive drugs, increases the risk of hypertension and cardiovascular disorders.

Tricyclic antidepressants increase the sympathomimetic effect of phenylephrine and may increase the risk of cardiovascular side effects.

Concomitant use of halothane with phenylephrine increases the risk of ventricular arrhythmia.

Phenylephrine reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenergic stimulating activity of phenylephrine.

Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation.

Simultaneous use of GCS with phenylephrine increases the risk of glaucoma.

Concomitant use with digoxin and cardiac glycosides may increase the risk of cardiac arrhythmias or heart attacks.

Ascorbic acid concomitantly with iron preparations, due to its reducing properties, converts trivalent to divalent iron, which improves its absorption.

Concurrent use of ascorbic acid increases iron excretion in patients receiving deferoxamine.

Concurrent use with barbiturates, primidone increases excretion of ascorbic acid in the urine.

Ascorbic acid in high doses may decrease urinary pH, which concomitantly reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

Concurrent use of acetylsalicylic acid reduces absorption of ascorbic acid by about a third.

Simultaneous use with warfarin may reduce the effects of warfarin.

Simultaneous use with tetracycline increases excretion of ascorbic acid with urine.

Special Instructions

The drug should not be taken simultaneously with other drugs containing paracetamol, as well as other non-narcotic analgesics (sodium metamisole), NSAIDs (acetylsalicylic acid, ibuprofen), with other drugs for relief of cold and flu symptoms, sympathomimetics (such as decongestants, appetite suppressants, amphetamine-like psychostimulants), barbiturates, anticonvulsants, rifampicin and chloramphenicol.

During the tests to determine uric acid and blood glucose levels the doctor should be informed about the use of the drug Coldrex® Junior, because the drug can distort the results of laboratory tests that assess the concentration of glucose and uric acid.

Before taking the drug it is necessary to consult a physician in case of:

-taking metoclopramide, domperidone (used to eliminate nausea and vomiting) or colestiramine used to reduce blood cholesterol concentration;
-taking drugs to reduce blood clotting (such as warfarin);
-maintaining a sodium-reduced diet – each sachet contains 0.Each sachet contains 0.12 g of sodium.

To avoid toxic liver damage paracetamol should not be combined with drugs containing ethanol.

Effect on the ability to drive vehicles and mechanisms

In case of dizziness the patient should refrain from driving vehicles or other potentially dangerous activities that require concentration and rapid psychomotor reactions.

Synopsis

Powder for preparation of oral solution (for children) heterogeneous, white to pale yellow in color, with a lemon smell;

Contraindications

– severe liver disease;
– severe kidney disease;
– diseases of the hematopoietic system;
– thyrotoxicosis;
– arterial hypertension;
– heart diseases (severe aortic stenosis, acute myocardial infarction, tachyarrhythmias);
– prostatic hyperplasia;
– closed-angle glaucoma;
– diabetes mellitus;
– genetic absence of glucose-6-phosphate dehydrogenase;
– glucose/isomaltase deficiency, intolerance of fructose, glucose-galactose malabsorption, as the preparation contains sodium carbamide.Administration of tricyclic antidepressants, beta-adrenoblockers, MAO inhibitors and up to 14 days after their withdrawal;
– children under 6 years old.
If your child has one of the above diseases / conditions / risk factors, be sure to consult with your doctor before taking the drug:

• Benign hyperbilirubinemia.
• Mild to moderate hepatic and renal dysfunction.
• Prostate disease and urinary problems.
• Cardiovascular disease, including high blood pressure, obliterating vascular disease (Raynaud’s syndrome).
• Glaucoma (excluding closed-angle glaucoma).
• Pheochromocytoma.
• The presence of severe infections, including sepsis, as drug administration may increase the risk of metabolic acidosis.
• Patients with glutathione deficiency (particularly in extremely malnourished patients with anorexia, chronic alcoholism or patients with low body mass index).
  

Side effects

Definition of the frequency of side effects: very frequently (≥1/10), frequently (≥1/100 and < 1/10), infrequently (≥1/1000 and < 1/100), rarely (≥1/10 000 and < 1/1000), very rarely (≥1/100 000 and < 1/10 000).
In recommended doses the drug is usually well tolerated.

Paracetamol rarely has side effects.

Hepatotoxic and nephrotoxic effects may be observed with prolonged use in excess of the recommended dose.
Allergic reactions: rare – skin rash, urticaria, allergic dermatitis, very rare – anaphylaxis, hypersensitivity reactions, including angioedema, oedema.

Respiratory system: very rare – bronchospasm in patients sensitive to acetylsalicylic acid and other NSAIDs.

The digestive system: very rarely – nausea, vomiting, liver function disorders.

CNS: very rarely – dizziness, headache, insomnia.

Senses: rare – mydriasis, acute glaucoma attack in most cases in patients with closed-angle glaucoma.

Cardiovascular system: rare – tachycardia, palpitations, increased BP.

Urinary system: very rarely – dysuria, urinary retention in patients with bladder outlet obstruction in prostatic hypertrophy.

In case of any adverse reactions the patient should consult a physician.

Overdose

In case of overdose of the drug Coldrex® Junior (even if you feel well) one should consider the risk of delayed signs of serious liver damage.

Symptoms due to paracetamol: within 24 hours – pale skin, decreased appetite, nausea, vomiting, abdominal pain. In 12-48 hours there may be signs of liver dysfunction, signs of impaired glucose metabolism and metabolic acidosis.