Colbiocin, eye ointment 5 g

A combined antibacterial drug for topical use in ophthalmology.

Chloramphenicol is a broad spectrum antibiotic, inhibits protein synthesis of susceptible microorganisms; active against Gram-positive and Gram-negative bacteria, Mycoplasma spp, Rickettsia spp., Chlamydia spp.; not active against Pseudomonas aeruginosa, fungi.

Tetracycline is a broad spectrum antibiotic that inhibits protein synthesis of bacteria at RNA level and has bacteriostatic action. It is active against Gram-negative bacteria, Chlamydia spp., Mycoplasma spp., Rickettsia spp., Entamoeba histolytica. Resistance of microorganisms develops slowly.< /p>

Sodium colistimethate is an antibiotic that is isolated from Bacillus polymixa, var. colistinus. It has a bactericidal effect on most gram-negative bacteria (including Pseudomonas spp., Haemophilus spp.); active against fungi. There is no cross-resistance with broad-spectrum antibiotics with which colistimethate sodium shows synergism.< /p>

Indications

Keratitis, Conjunctivitis, Blepharitis

• conjunctivitis (catarrhal, purulent, trachoma);
• blepharitis;
blepharoconjunctivitis;
• bacterial keratitis;
• septic corneal ulcer;
• dacryocystitis.

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Active ingredient

Sodium colistimethate, Tetracycline, Chloramphenicol

Composition

The ointment is semi-solid, yellow.

1 g chloramphenicol10 mg sodium colistimethate180 ths.Metetracycline5 mg

Auxiliary substances: petroleum jelly, lanolin, petroleum jelly.

How to take, the dosage

The eye ointment should be placed in the lower conjunctival sac 3-4 times a day. If the ointment is combined with the use of eye drops, the ointment may be applied only once a day (before bedtime).

Interaction

There are no drug interactions between Colbiotin and other drugs for topical use.

Special Instructions

If there is no significant clinical improvement within a relatively short period of time or if allergic reactions occur, Colbiocin should be discontinued and appropriate anti-allergy therapy provided.

There have been rare cases of bone marrow hypoplasia due to long-term topical use of chloramphenicol.Because rare cases of bone marrow hypoplasia have been reported due to prolonged topical use of chloramphenicol, Colbiocin should be used for short periods of time and under the supervision of an ophthalmologist.

Contraindications

• individual hypersensitivity to the components of the drug
• disorder of liver and kidney function
• pregnancy
• lactation period
• children (under 8 years).

Side effects

Local reactions: transient conjunctival hyperemia, burning sensation.

Allergic reactions: angioedema, urticaria, bullous and patchy-papular dermatitis.

Overdose

There have been no reported cases of overdose of Colbiotin.

Pregnancy use

The drug is contraindicated in pregnancy and during lactation (breastfeeding).

Prevent use in children

The drug is contraindicated in children under 8 years of age.