Clarithromycin 500 mg, 10 pcs.

Clarithromycin is an antibiotic of macrolide group that inhibits protein synthesis in a microbial cell by interacting with 50S ribosomal subunit of bacteria. It is active against Streptococcus agalactiae (pyogenes, viridans, pneumoniae), Haemophilus influenzae (parainfluenzae), Neisseria gonorrhoeae, Listeria monocytogenes, Legionella pneumophilia, Mycoplasma pneumoniae, Helicobacter pylori, Campilobacter jejuni, Chlamydia pneumoniae (trachomatis), Moraxella (Branhamella) catarrhalis, Bordetella pertussis, Propionibacterium acnes, Mycobacterium avium, Mycobacterium leprae, Staphylococcus aureus, Ureaplasma urealyticum, Toxoplasma gondii.

When administered orally clarithromycin is metabolized to form the main metabolite 14hydroxyclarithromycin which has the same or 1-2 orders of magnitude less (depending on the type of microorganism) antimicrobial activity than the unchanged substance.

Indications

Infections caused by clarithromycin-sensitive microorganisms – Upper respiratory tract infections (laryngitis, pharyngitis, tonsillitis and sinusitis);

lower respiratory tract infections (bronchitis, bacterial pneumonia);

infections of the skin and soft tissues (folliculitis, furunculosis, impetigo, wound infection);

infections caused by Mycobacterium avium, Chlamydia trachomatis, Helicobacter pylori, Ureaplasma urealyticum.

Active ingredient

Composition

1 tablet contains 0.5 g clarithromycin

How to take, the dosage

The dosage regimen and duration of treatment are determined individually, taking into account the indications, the severity of the infection and the sensitivity of the pathogen.

In adults and children over 12 years of age, the average dose is 250 mg twice daily. If necessary, clarithromycin may be prescribed 500 mg twice daily. The duration of treatment is 5-14 days.

In the treatment of infections caused by Mycobacterium avium, sinusitis, severe infections, including those caused by Haemophilus influenzae – 500-1000 mg 2 times a day; maximum daily dose is 2 g.

In children under 12 years of age the dose is 7.5 mg/kg of body weight every 12 hours; maximum daily dose is 500 mg. In patients with renal insufficiency (in creatinine Cl less than 30 ml/min or serum creatinine concentration more than 3.3 mg/100 ml) the dose should be reduced by half. Maximum duration of treatment in patients in this group is not more than 14 days.

Interaction

Concomitant administration of clarithromycin with theophylline and carbamazepine has increased plasma levels of the latter.

Contraindications

A hypersensitivity to macrolides.

Side effects

Nausea, vomiting, epigastric pain, diarrhea, transient increase in liver transaminase activity, skin rash, headache are possible.

Overdose

Symptoms: nausea, vomiting, diarrhea.

Treatment: flush the stomach as quickly as possible, administer symptomatic therapy.

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