Chronotron 20 mg/ml 2 ml, syringe

Joint diseases accompanied by pain syndrome, caused by degenerative or post-traumatic conditions or changes in the joints. This product, thanks to its visco-elastic and lubricating properties, allows the restoration of optimal rheological and physiological conditions for the functioning of the joints. By improving the characteristics of synovial fluid, the product protects the joints. These properties help to improve joint function and reduce joint pain.

Active ingredient

Polynucleotides

Composition

Each prefilled syringe contains: 20 mg/ml polynucleotides, water for injection, sodium chloride, single-base sodium phosphate dihydrate, dodecahydrate of double-base sodium phosphate.

How to take, the dosage

The product should be administered as intra-articular injections, using a sterile 20G needle. Intra-articular injection must be performed by a qualified physician, in accordance with the technical requirements and aseptic rules to be observed for this mode of administration. Given the viscosity of the solution, the needle should be tightly threaded onto the luer tip of the syringe barrel in order to ensure tightness and prevent leakage of the solution between the needle and syringe during product application.

Dosage
In general, unless otherwise advised by the physician: Make one intra-articular injection with 2.0 ml of the product (40 mg polynucleotide), once a week for 3-6 weeks.

Special Instructions

Precautions for use
The product is intended for single use.
The product should be used with extreme caution in case of congestion in the lymphatic or venous system of the lower extremity whose joints are being treated. It is recommended to eliminate any signs of joint swelling (if any), before starting the administration of the product. Patients receiving intra-articular injections should avoid vigorous physical activity that could damage the joint, and resume standard activity after several days.
The product should not be used simultaneously with disinfectants containing quaternary ammonium salts or chlorhexidine.
The product should not be injected intravascularly, periarticularly, into the synovial membrane, or into the joint capsule.
The product should not be injected if there is contamination in the syringe.

Special Notes
Intra-articular injections should only be performed by medical professionals.
Before using the syringe, make sure that the packaging is completely sealed: do not use if the sterile packaging is damaged or has already been opened. Do not use the product after the expiration date printed on the package. The expiration date refers to the unopened product if stored correctly. The product should be used immediately after opening and disposed of after use.
The product should only be distributed as prescribed by a physician.

Synopsis

The product is a viscoelastic, clear and colorless solution containing polynucleotides, which is in a glass, pre-filled, apyrogenic, sterile syringe for single use, with 2 ml of solution. The highly purified polynucleotides are obtained from fish tissue and are presented at a concentration of 20 mg/ml. Since the product is characterized by its viscoelastic properties and high ability to bind significant amounts of water molecules, it acts as a lubricant and helps to normalize the viscosity of the synovial fluid.

Contraindications

The use of CHRONOTRON® is contraindicated in patients with hypersensitivity to any of the product components, or with a history of allergic reactions to products derived from fish tissue. The product should not be injected into joints with signs of infection or pronounced inflammation, or in cases where the patient has a current infection localized in the vicinity of the injection site to prevent the development of bacterial arthritis. The efficacy and safety of CHRONOTRON® have not been established in pregnant women, breastfeeding women and children.

Side effects

During the use of CHRONOTRON, some unwanted effects associated with the clinical practice of intra-articular injections may occur, including localized pain, fever, redness and swelling.

These symptoms can be treated by resting the joint and applying ice to the joint, and these symptoms are usually resolved within a short period of time. If symptoms persist, a physician should be consulted. Physicians should advise patients to report any adverse events that may develop after treatment.