Chondroksid, tablets, 60 pcs.

Chondroxide has a chondrostimulating, regenerating and anti-inflammatory effect. Participates in the construction of the basic substance of cartilage and bone tissue; affects the metabolic processes in the hyaline and fibrous cartilage.

Inhibits the processes of degeneration (destruction) of cartilage and connective tissue; inhibits the enzymes that cause cartilage damage.

Hondroxide stimulates proteoglycan biosynthesis, promotes regeneration of the articular bag and cartilage surfaces of joints, increases production of intra-articular fluid and leads to a decrease in inflammation.

Potentially can inhibit the formation of fibrin clots in the synovial and subchondral and microcirculatory beds.

Hondroxide slows the progression of osteoarthritis and osteochondrosis, normalizes metabolism in hyaline tissue, stimulates regenerative (repair) processes in articular cartilage.

The use of the drug Khondroksid reduces pain and improves mobility of affected joints, while the therapeutic effect is maintained long after the therapy course is over.

Pharmacokinetics

On single oral administration of an average therapeutic dose the maximum concentration in plasma is reached after 3-4 hours and in synovial fluid after 4-5 hours.

The drug mostly accumulates in the cartilage (maximum concentration in articular cartilage is reached after 48 hours); synovial membrane is not an obstacle for its penetration into the joint cavity. It is eliminated by the kidneys within 2 hours.

Dimethylsulfoxide, which is part of the ointment, promotes better penetration of chondroitin sulfate through the cell membranes into the deep tissues and has some anti-inflammatory, analgesic and fibrinolytic effect.

Hondroxide gel is well absorbed, does not leave marks on the skin and does not stain clothes.

Indications

Degenerative-dystrophic diseases of the joints and spine:

Active ingredient

Composition

1 tablet contains:

The active ingredient:

Chondroitin sulfate – 250.0 mg (in terms of 100% dry matter);

Auxiliary substances:

Calcium stearate monohydrate (calcium stearate 1-water),

Crospovidone (polyplasdon XL-10, collidone CL-M),

Povidone K-30 (collidon 30),

Microcrystalline cellulose,

Magnesium hydroxycarbonate pentahydrate (magnesium carbonic acid basic aqueous).

How to take, the dosage

Overly, 0.5 g (2 tablets) 2 times a day.

The tablets are taken with a small amount of water.

The recommended initial course of treatment is 6 months.

Please note that the therapeutic effects of the drug last for 3 to 5 months after discontinuation, depending on the location and stage of the disease.

If necessary, repeated courses of treatment may be taken and the duration of these courses is determined individually.

Interaction

Possible enhancement of the effect of indirect anticoagulants, antiaggregants, fibrinolytics.

Special Instructions

When co-administration of the drug with indirect anticoagulants, antiaggregants, fibrinolytics, more frequent monitoring of blood clotting is required.

The efficacy and safety of chondroitin sulfate in children have not been established.

Contraindications

With caution, use the drug in case of bleeding or when you are prone to bleeding.

Side effects

Frequency assessment: rare – from >= 0.01% to < 0.1%.

Gastrointestinal tract disorders: rare – nausea, vomiting, diarrhea.

Immune system disorders: rare – allergic reactions.

Overdose

Symptoms: rare – nausea, vomiting, diarrhea, with prolonged use in excessive doses (more than 3 g/day) hemorrhagic rash is possible.

Treatment: conducting symptomatic therapy.

Pregnancy use

Hondroxide is contraindicated in pregnancy and lactation.

Similarities