Chondroitin-ACOS, ointment 5% 50 g

Pharmacotherapeutic group: Tissue regeneration stimulator

ATC code: M01AX25

Pharmacodynamics:

Chondroitin sulfate is a high molecular weight mucopolysaccharide slows bone tissue resorption and reduces calcium loss. Improves calcium-phosphorus metabolism in cartilage tissue. Accelerates the process of its restoration inhibits the process of degeneration of cartilage and connective tissue. Inhibits enzymes that cause cartilage tissue damage stimulates the synthesis of glycosaminoglycans promotes the regeneration (restoration) of the joint capsule and cartilage surfaces increases production of intra-articular fluid. Due to its structural proximity to heparin, it prevents the formation of fibrin clots in the synovial and subchondral microcirculatory system. Reduces pain and increases the mobility of affected joints. Slows the progression of osteoarthritis.

Dimethylsulfoxide contained in the ointment has anti-inflammatory analgesic and fibrinolytic effect promotes better penetration of chondroitin sulfate through cell membranes.

Pharmacokinetics:

According to the data obtained in experimental studies with mice using radiolabeled 3H-chondroitin sulfate the absorption rate of chondroitin sulfate is 14%.

The dimethyl sulfoxide in the ointment promotes better penetration of chondroitin sulfate through cell membranes into the deep tissues.

Chondroitin sulfate enters the joint after application of the ointment on the skin with maximum concentration reached after 30 min followed by biphasic elimination of the drug from the cartilage tissue. Completion of the fast phase of excretion occurs 1 hour after application. Retention time of the drug in the joint is 5 hours.

Indications

Active ingredient

Composition

About 100 g:

Active substance: chondroitin sulfate sodium (in terms of dry substance) – 5.0 g;

Auxiliary substances: dimethyl sulfoxide (dimethoxide), lanolin (waterless lanolin), vaseline (medical vaseline), purified water.

How to take, the dosage

In the outside!

The Chondroitin-ACOS ointment is applied 2-3 times a day to the skin over the lesion and rubbed for 2-3 minutes until completely absorbed. The course of treatment is 2-3 weeks. The course of treatment is repeated if necessary.

In severe cases chondroitin sulfate preparations are prescribed simultaneously for intravenous or intramuscular injections.

Interaction

Special Instructions

Avoid getting the ointment on the mucous membranes and open wounds.

Do not use the drug without medical advice under 18 years of age.

Impact on the ability to drive vehicles and machines:

Chondroitin-ACOS Ointment has no effect on the ability to drive vehicles and engage in potentially hazardous activities requiring increased concentrated attention and rapid psychomotor reactions.

Contraindications

Do not use Chondroitin-ACOS ointment without medical advice in pregnancy and during lactation (breastfeeding).

Age under 18 years of age.

Side effects

In rare cases, allergic reactions are possible, in which case the drug should be discontinued.

If you notice any other side effects not mentioned in the instructions, tell your doctor.

Overdose

Pregnancy use

Similarities