Chlorhexidine Bigluconate 0.05% SFP, 100 ml

How to take, the dosage

Chlorhexidine is used as a preventive and therapeutic agent topically and locally, as well as for disinfection.

The 0.05%, 0.02% and 0.5% aqueous solutions are used as irrigations, rinses and applications (5-10 ml are applied to the affected skin surface or mucous membranes):

• To treat the operating field, dilute 20% solution with 70% ethyl with exposure for 1-3 minutes 2-3 times a day (on a tampon or by irrigation).
• Alcohol in a ratio of 1:40. The obtained 0.5% chlorhexidine water-alcohol solution is used to treat the surgical field 2 times at 2 minute intervals.
• In post-operative care of patients in ENT and dental departments the solution (0.05% and 0.1%) for gargling is usually prescribed 2-3 times a day.
• For bladder irrigation, at cystoscopy use 0.02% sterile aqueous solution.
• For prevention of venereal diseases, chlorhexidine bigluconate is effective if used not later than 2 hours after sexual intercourse.

Diluted, 0.05% solution, is injected into the urethra in men (2-3 ml), in women (1-2 ml) and in the vagina (5-10 ml) for 2-3 minutes. It is also necessary to treat the skin on the inner surfaces of the thighs, pubis, genitals. After the procedure, do not urinate for 2 hours.

To disinfect:

Treat medical instruments and working surfaces with a clean sponge dampened with antiseptic solution or by soaking. For rapid sterilization of instruments the same 0.5% solution is used for 5 minutes.

The 0.1% aqueous chlorhexidine solution can also be used for disinfecting rooms, sanitary equipment, etc.

Interaction

It is used in a neutral medium; at pH 5-8 there is little difference in activity; at pH over 8 there is precipitation. The use of hard water slightly reduces the bactericidal properties.

Chlorhexidine bigluconate is a cationic substance and does not combine with soaps and other anionic compounds such as colloids, gum arabic, carboxymethylcellulose.

At a concentration of 1:2000, it is incompatible with borates, carbonates, chlorides, citrates, phosphates, and sulfates, creating a hard-to-solve precipitate after 24 hours.

Compatible with preparations containing cationic group (benzalkonium chloride, centrimonium bromide).

It increases the sensitivity of bacteria to chloramphenicol, kanamycin, neomycin, cephalosporins.

Ethanol increases the effectiveness of the drug.

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Special Instructions

In patients with open craniocerebral trauma, spinal cord injury, tympanic membrane perforation, avoid contact of the drug with the surface of the brain, the meninges and the tympanic cavity.

In case of contact with the mucous membranes of the eyes, they should be rinsed quickly and thoroughly with water.

The simultaneous use with iodine is not recommended.

Chlorhexidine should not be mixed with other disinfectants and detergents. Contact with hypochlorous bleaching agents on fabrics that have previously been in contact with chlorhexidine-containing products can contribute to brown stains.

Clothing that has been in contact with chlorhexidine should not be exposed to hypochlorites and other compounds that release active chlorine.

Do not dilute with hard water. Aqueous solutions can be sterilized in an autoclave at 116°C for 30 minutes. Do not sterilize with ionizing radiation.

Contraindications

Hypersensitivity to the components of the drug, dermatitis.
With caution – children (under 18 years).

Side effects

In rare cases, allergic reactions (skin rash), dry skin, itching, dermatitis, sticky skin on hands (for 3-5 minutes), photosensitization are possible.

Tooth discoloration, tartar buildup and taste disorder with long-term use for oral antisepsis.

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Overdose

In case of accidental ingestion, it is practically not absorbed (gastric lavage should be done with milk, raw egg, gelatin or mild soap). If necessary, symptomatic therapy is carried out.

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Similarities

Hexicon, Chlorhexidine, Chlorhexidine Vialine