Cetrin, 10 mg 20 pcs.

Pharmacodynamics

Competitive histamine antagonist, hydroxyzine metabolite, blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects. It affects the early stage of allergic reactions, limits the release of inflammatory mediators at the “late” stage of the allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. It reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm.

It eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). It reduces histamine-induced bronchoconstriction in mild bronchial asthma.
It has almost no anticholinergic and antiserotonin action.

In therapeutic doses the sedative effect is practically absent. The beginning of the effect after a single dose of 10 mg of cetirizine is 20 minutes and lasts for more than 24 hours. During the course of treatment tolerance to antihistamine action of cetirizine does not develop. After discontinuation of treatment the effect lasts up to 3 days.

Pharmacokinetics

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Pharmacokinetic interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam and glipizide was not found.

The co-administration with theophylline (400 mg/day) results in decreased total clearance of cetirizine (the kinetics of theophylline is not altered).

Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Special Instructions

The ability to react quickly may be impaired if the dose of 10 mg/day is exceeded.

In recommended doses it does not increase the effect of ethanol (at its concentration not more than 0.8 g/l), however, it is recommended to refrain from its use during treatment.

For children (from 2 years of age) Cetrin® is used in the form of syrup.

When using this medicine, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Synopsis

Contraindications

Side effects

Overdose

Symptoms (occurs with a single dose of 50 mg) – dry mouth, drowsiness, delayed urination, constipation, restlessness, increased irritability.

Treatment:Gastric lavage, prescription of symptomatic drugs.

There is no specific antidote.

Hemodialysis is ineffective.

Pregnancy use

Similarities