Cetirizine-Vertex, 10 mg 10 pcs

Pharmgroup:

anti-allergic agent – H1-histamine receptor blocker. Pharmacological action: A competitive histamine antagonist, a metabolite of hydroxyzine, blocks H1-histamine receptors. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action.

It affects the early stage of allergic reactions, limits the release of inflammatory mediators at the “late” stage of allergic reaction, reduces migration of eosinophils, neutrophils and basophils. It reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm.

Limits the skin reaction to the introduction of histamine, specific allergens, as well as to cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in mild bronchial asthma. Practically has no anticholinergic and antiserotonin action.

In therapeutic doses practically does not cause sedative effect. The beginning of the effect after a single dose of 10 mg of cetirizine is 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients) and lasts more than 24 hours. During a course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After discontinuation of treatment the action lasts up to 3 days.

Indications

Active ingredient

Composition

Filmed film-coated tablets.

1 film-coated tablet contains:

the active substance:

cetirizine dihydrochloride 10 mg;

auxiliary substances:

microcrystalline cellulose,

lactose monohydrate,

p> crospovidone,

magnesium stearate,

colloidal silicon dioxide.

The composition of the shell:

[hypromellose, talc, titanium dioxide, macrogol 4000] or [film dry white shell containing hypromellose, talc, titanium dioxide, macrogol 4000].

How to take, the dosage

Orally, tablets with 200 ml of water, dissolve the drops in water before intake.

Adults and children over 6 years of age – 10 mg once a day or 5 mg 2 times a day, children 2-6 years of age – 5 mg once a day or 2.5 mg 2 times a day, children 1-2 years of age – 2.5 mg (5 drops) 2 times a day.

In patients with reduced renal function (CKD 30-49 ml/min), 5 mg/day is prescribed; in severe CKD (CKD 10-30 ml/min), 5 mg/day every other day.

Interaction

Pharmacokinetic interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam and glipizide was not found.

Co-administration with theophylline (400 mg/day) decreases total clearance of cetirizine (the kinetics of theophylline is not altered). Myelotoxic drugs increase manifestations of hematotoxicity of the drug.

Special Instructions

The ability to react quickly may be impaired if the dose of 10 mg/day is exceeded.

In the recommended doses it does not increase the effect of ethanol (at its concentration not more than 0.8 g/l), however, it is recommended to refrain from its use during treatment.

When taking this medicine, caution should be exercised while driving vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Developed renal function (creatinine clearance 30-49 ml/min); chronic renal failure; children under 6 years of age; pregnancy; lactation; hypersensitivity to cetirizine, other drug components, hydroxyzine.

With caution: advanced age (decreased glomerular filtration is possible).

Side effects

Sleepiness, dry mouth; rarely – headache, dizziness, migraine, GI discomfort, allergic reactions (angioedema, rash, urticaria, itching).

Overdose

Symptoms (occurs with a single dose of 50 mg) – dry mouth, drowsiness, delayed urination, constipation, restlessness, increased irritability.

Treatment: gastric lavage, prescription of symptomatic medications. There is no specific antidote. Hemodialysis is ineffective.

Pregnancy use

It is contraindicated during pregnancy and lactation.

Similarities