Ceresil Canon, 125 mg/ml 4 ml 5 pcs

Pharmacodynamics

Citicoline is a natural endogenous compound, which is an intermediate metabolite in the synthesis of phosphatidylcholine, one of the main structural components of the cell membrane. Citicoline, being a precursor of the key ultrastructural components of the cell membrane (mainly phospholipids), has a broad spectrum of action – it helps restore damaged cell membranes, inhibits phospholipases, prevents the excessive formation of free radicals and prevents cell death by interfering with apoptosis mechanisms.

In the acute period of stroke citicoline reduces the amount of brain tissue damage, improves cholinergic transmission. In craniocerebral trauma reduces the duration of post-traumatic coma and severity of neurological symptoms, and also reduces the duration of the recovery period. In chronic cerebral hypoxia citicoline is effective in treating cognitive disorders such as memory impairment, lack of initiative, difficulties in daily activities and self-care. Increases the level of attention and consciousness, and reduces the manifestation of amnesia.

Citicoline is effective in the treatment of sensory and motor neurological disorders of degenerative and vascular etiology.

Pharmacokinetics

absorption

Citicoline is well absorbed when taken orally. Absorption after oral administration is almost complete and bioavailability is approximately the same as after intravenous administration.

Distribution

Citicoline is largely distributed in brain structures, with rapid incorporation of choline fractions into structural phospholipids and citidine fractions into citidine nucleotides and nucleic acids.
Citicoline penetrates the brain and is actively incorporated into cellular, cytoplasmic and mitochondrial membranes, forming part of the structural phospholipid fractions.

Metabolism

The drug is metabolized in the intestine and in the liver to form choline and cytidine. After ingestion, the plasma concentration of choline increases significantly.
Excretion

Only 15% of the administered dose of citicoline is excreted from the human body: less than 3% – by the kidneys and through the intestines and about 12% – with exhaled CO2.
Two phases can be distinguished in the excretion of citicoline with urine: the first phase lasting about 36 hours, during which the excretion rate decreases rapidly, and the second phase, during which the excretion rate decreases much slower. The same is observed in exhaled CC2 – the excretion rate decreases rapidly after about 15 hours and then decreases at a much slower rate.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

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