Carnitetine, capsules 295 mg 60 pcs

Acetyl-L-carnitine (ALA), a natural biologically active substance, under physiological conditions is present in the body in various organs and tissues, including the CNS and participates in the metabolism of fatty acids and carbohydrates.

The pharmacological and biological action of ALA is largely due to the metabolic effects of L-carnitine and the acetyl group contained in its composition. Acetyl-L-carnitine (ALA), the biologically active form of L-carnitine, a key substance in the process of fat catabolism and energy formation in the body. ALA is synthesized in the brain tissue, liver and kidneys from L-carnitine with the participation of the enzyme carnitine acetyltransferase.

Because ALA delivers activated acetate directly to the mitochondrial matrix to form acetyl-CoA, which is involved in the tricarboxylic acid cycle, without additional energy expenditure, it is a readily available substrate to trigger energy-dependent metabolic processes in mitochondria. By providing a full energy supply to the body with less tissue oxygen consumption, ALA protects brain tissue from ischemia.

Owing to its structural similarity to acetylcholine, ALA has a cholinomimetic effect and also shows neuroprotective properties. It increases the cellular concentration of asparagic and glutamic acid and taurine. With long-term use, it increases the density of N-methyl-D-aspartate receptors in the hippocampus, cortex and striatum and inhibits their decrease under aging conditions. ALA enhances the effects of serotonin and also protects brain cells from the neurotoxic effects of ammonia and glutamate.

The results of experimental studies have shown that ALA has anti-amnesic activity, the ability to improve learning processes and parameters of non-associative memory and have a positive effect on mnastic functions in the experimental model of Alzheimer’s disease without causing sedative and muscle relaxant side effects.

ALA increases the production of energy, which is a readily available substrate for the triggering of energy-dependent metabolic processes in the mitochondria. It stimulates the synthesis of proteins and phospholipids for building membranes and improves regeneration processes.

In pathology it has a neuroprotective effect, especially in relation to neurons and their organelles (mitochondria) and neurotrophic effect by modulating the activity of nerve growth factor (NFG). It has antioxidant and membrane stabilizing effects. ALA can accelerate nerve cell regeneration in traumatic and endocrine damage of peripheral nerves in experimental models of polyneuropathy in diabetes.

The remarkable effect of ALA is to slow the aging process by enhancing the transport of fatty acids into the mitochondria and maintaining their function at the level of a young body. ALA can accelerate nerve cell regeneration in traumatic and endocrine damage of peripheral nerves in experimental models of diabetes.

Indications

• Early dementia of Alzheimer’s type (Alzheimer’s disease) and cerebral vascular dementia;
• Peripheral neuropathy of different etiology;
• Decrease of mental performance, to improve concentration and memory.

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Active ingredient

Acetylcarnitine

Composition

Acetylcarnitine hydrochloride (carnitetine) 0.295 g.

Excipients:

microcrystalline cellulose (MCC);

colloidal silicon dioxide (aerosil A-300);

Magnesium stearate – to obtain the mass of the capsule contents of 0.34 g.

Hard gelatin capsules:

Capsule composition – gelatin;

Glycerol (glycerin);

nipagine (methylparahydroxybenzoate);

nipazole (propyl parahydroxybenzoate);

sodium lauryl sulfate;

purified water,

titanium dioxide.

How to take, the dosage

Ingestion. A single dose for adults is usually 1-4 capsules, a daily dose is 6-12 capsules.

The course of treatment is 1-4 months.

Interaction

There have been no reported cases of drug interactions.

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Contraindications

• Individual hypersensitivity to Carnitetin;
• Age under 18 years of age (efficacy and safety not established).

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Side effects

Possible allergic reactions; nausea, heartburn.

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Overdose

There have been no recorded cases of overdose.

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Pregnancy use

Специальных исследований о возможности применения при беременности и в период грудного вскармливания не проводилось;

применяют только в случае, если предполагаемая польза для матери превышает риск для плода.

На время лечения следует прекратить грудное вскармливание.