Candide, vaginal tablets 500 mg

Candid – broad spectrum antifungal.

Pharmacodynamics

The antimycotic effect of the active active ingredient – clotrimazole (imidazole derivative) is associated with disruption of ergosterol synthesis, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis.

In low concentrations it is fungistatic and in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of fungal cells.

It is effective against dermatophytes, yeast-like and mold fungi as well as against the causative agent of variegated lichen (Pityriasis versicolor) and erythrazma causative agent. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.

Indications

genital infections caused by yeast-like fungi of the genus Candida and/or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
genital superinfections caused by microorganisms sensitive to clotrimazole;
sanitation of the birth canal before childbirth.

Pharmacological effect

Candida is a broad spectrum antifungal.

Pharmacodynamics

The antimycotic effect of the active ingredient – clotrimazole (imidazole derivative) is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

In small concentrations it has a fungistatic effect, in large concentrations it has a fungicidal effect, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of pityriasis versicolor (Pityriasis versicolor) and the causative agent of erythrasma. It has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.

Active ingredient

Clotrimazole

Composition

Vaginal tablets

1 tablet contains:

Active substance:

Clotrimazole 500 mg

Excipients:

Lactose

Starch

Sodium carboxymethyl starch

Purified talc

Magnesium stearate

Silicon dioxide colloidal

Methyl parahydroxybenzoate (methylparaben)

Propyl parahydroxybenzoate (propylparaben)

Contraindications

hypersensitivity to clotrimazole or excipients;
I trimester of pregnancy;
period of menstruation.

With caution: breastfeeding period.

Overdose

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

Symptoms (in case of unintended oral use of the drug): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely – drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: administration of activated carbon, if necessary, symptomatic therapy; there is no specific antidote.

Action

Itching, burning and swelling of the vaginal mucosa, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of the sexual partner, pain during sexual intercourse.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

Glenmark Pharmaceuticals Ltd, India