Candide, 1% solution 15 ml

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent. Antifungal effect is associated with disruption of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes changes in its structure and properties and leads to cell lysis.

In low concentrations it is fungistatic, in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of fungal cells.

It is effective against dermatophytes (Epidermophyton, Microsporum, Trichophyton), yeasts (mainly Candida albicans), mold fungi and protozoa, as well as the causative agent of variegated lichen Pityriasis versicolor and erythrazma. It has antimicrobial action against Gram-positive microorganisms and anaerobes. Clotrimazole has no effect on lactobacilli.

When applied topically there is little adsorption of clotrimazole from mucous membranes.

Indications

Candida stomatitis.

Active ingredient

Clotrimazole

Composition

Active ingredient:

clotrimazole 10 mg;

excipients:

propylene glycol – 495 mg,

glycerin – 495 mg.

How to take, the dosage

Topically, 10-20 drops (0.5-1 ml) are applied to the affected areas of the mouth with a cotton swab 3-4 times a day.

The condition usually improves on the 3rd-5th day of treatment.

The duration of treatment is until the clinical manifestations of the disease are completely eliminated.

Interaction

Combined use with amphotericin B, nystatin may decrease the activity of clotrimazole.

If you use the above or other medicines (including over-the-counter drugs), consult your doctor before using Candida.

Special Instructions

The drug is intended for topical application in the oral cavity only.

Contraindications

Hypersensitivity to clotrimazole and other components of the drug.

Side effects

The drug is usually well tolerated. In rare cases of hypersensitivity to the drug components allergic reactions – redness of the oral mucosa, burning and tingling sensation at the application site, urticaria. If irritation occurs, do not use the drug.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

The use of the drug in high doses does not cause any reactions and life-threatening conditions.

Symptoms (in case of unintended use of the drug orally): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely – somnolence, hallucinations, pollakiuria, skin allergic reactions.

Treatment: administration of activated charcoal, if necessary – symptomatic therapy; there is no specific antidote.

Similarities

Candide, Clotrimazol-Acrihin, Clotrimazol, Clotrimazol-Teva