Candide, vaginal gel 2% 30 g

Pharmacological action – antifungal topical.

Pharmacodynamics
Antimycotic effect of clotrimazole is associated with disruption of ergosterol synthesis, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis. In low concentrations it is fungistatic and in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations it interacts with mitochondrial and peroxidase enzymes resulting in increase of hydrogen peroxide concentration to toxic level, which also promotes fungus cell destruction.

Effective against dermatophytes, yeast-like and mold fungi as well as Pityriasis versicolor and erythrasma pathogen. It has antimicrobial action against Gram-positive (staphylococcus, streptococcus) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis) as well as against Trichomonas vaginalis.

Pharmacokinetics
When clotrimazole is administered intravaginally, absorption is 3-10% of the administered dose. High concentrations in vaginal secretion and low concentrations in blood persist for 48-72 hours. In the liver it is quickly metabolized to inactive metabolites.

Indications

Active ingredient

Composition

1 g of the gel contains:

The active ingredient:

Clotrimazole 20 mg;

Associates:

Cetyl alcohol;

Propylene glycol, glycerol;

Benzyl alcohol;

Cetomacrogol emulsion wax;

Carbopol 940 (carbomer 940);

Sodium hydroxide;

Chlorocresol;

Purified water.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

Similarities