Candide, powder 1% 30 g

Candide – a broad spectrum antifungal.

Pharmacodynamics

Antimycotic effect of the active ingredient – clotrimazole (imidazole derivative) is associated with disruption of ergosterol synthesis, a component of the cell membrane of fungi, which changes membrane permeability and causes subsequent cell lysis.

In small concentrations it is fungistatic, in large concentrations it is fungicidal, and not only on proliferating cells.

In fungicidal concentrations it interacts with mitochondrial and peroxidase enzymes resulting in the increase of hydrogen peroxide concentration to the toxic level, which also contributes to the destruction of fungus cells.

Effective against dermatophytes, yeast-like and mold fungi as well as Pityriasis versicolor and erythrazma pathogen.

Indications

dermatophytosis of the head (including the face), body, legs;
mycosis of nails;
pityriasis versicolor;
skin candidiasis;
candidal paronychia;
candidiasis vulvitis;
candidal balanitis;
candidiasis of the external genitalia and anus;
fungal diaper dermatitis;
erythrasma.

Pharmacological effect

Candida is a broad spectrum antifungal.

Pharmacodynamics

The antimycotic effect of the active ingredient – clotrimazole (imidazole derivative) is associated with a disruption of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis.

In small concentrations it has a fungistatic effect, in large concentrations it has a fungicidal effect, and not only on proliferating cells.

At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of pityriasis versicolor (Pityriasis versicolor) and the causative agent of erythrasma.

Active ingredient

Clotrimazole

Composition

1 g of powder contains:

Active substance:

clotrimazole 10 mg;

Excipients:

purified talc;

corn starch;

colloidal silicon dioxide;

cosmetic fragrance.

Contraindications

specific skin lesions (including tuberculosis, chicken pox, herpes simplex, measles, syphilis);
skin reactions at the vaccination site;
hypersensitivity to the components of the drug.

Side Effects

Itching, burning and swelling of the vaginal mucosa, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of the sexual partner, pain during sexual intercourse.

Overdose

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

Symptoms (in case of unintended oral use of the drug): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely – drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: administration of activated carbon, if necessary, symptomatic therapy; there is no specific antidote.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

Glenmark Pharmaceuticals Ltd, India