Candide, 1% solution 15 ml

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent. Antifungal effect is associated with disruption of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes changes in its structure and properties and leads to cell lysis.

In low concentrations it is fungistatic, in high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in hydrogen peroxide concentration to toxic levels, which also contributes to the destruction of fungal cells.

It is effective against dermatophytes (Epidermophyton, Microsporum, Trichophyton), yeasts (mainly Candida albicans), mold fungi and protozoa, as well as the causative agent of variegated lichen Pityriasis versicolor and erythrazma. It has antimicrobial action against Gram-positive microorganisms and anaerobes. Clotrimazole has no effect on lactobacilli.

When applied topically there is little adsorption of clotrimazole from mucous membranes.

Indications

Candidal stomatitis.

Pharmacological effect

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent. The antifungal effect is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.

In low concentrations it acts fungistatically, in high concentrations it has a fungicidal effect, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Effective against dermatophytes (Epidermophyton, Microsporum, Trichophyton), yeasts (mainly Candida albicans), molds and protozoa, as well as the causative agent of pityriasis versicolor and the causative agent of erythrasma. Has an antimicrobial effect against gram-positive microorganisms and anaerobes. Clotrimazole has no effect on lactobacilli.

When applied topically, the adsorption of clotrimazole from the mucous membranes is insignificant.

Special instructions

The drug is intended for topical use in the oral cavity only.

Active ingredient

Clotrimazole

Composition

Active ingredient:

clotrimazole 10 mg;

excipients:

propylene glycol – 495 mg,

glycerin – 495 mg.

Contraindications

Hypersensitivity to clotrimazole and other components of the drug.

Side Effects

The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are observed – redness of the oral mucosa, burning and tingling sensation at the site of application of the drug, urticaria. If irritation occurs, do not use the drug.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When used simultaneously with amphotericin B and nystatin, the activity of clotrimazole may decrease.

If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Candide.

Overdose

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

Symptoms (in case of unintended oral use of the drug): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely – drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: administration of activated carbon, if necessary, symptomatic therapy; there is no specific antidote.

Storage conditions

The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life

3 years

Manufacturer

Glenmark Pharmaceuticals Ltd, India