Calcium gluconate, 10% 5 ml 10 pcs

Pharmacodynamics

Calcium ions are involved in transmission of nerve impulses, contraction of smooth and transverse striated muscles, myocardial function, blood clotting; they are necessary for bone formation, functioning of other systems and organs.

The concentration of calcium ions in blood decreases in many pathological processes; severe hypocalcemia contributes to tetany. Besides elimination of hypocalcaemia calcium compounds reduce vascular permeability and have anti-allergic, anti-inflammatory and hemostatic activity.

Pharmacokinetics

After parenteral administration the drug is evenly distributed in all tissues and organs. In blood plasma calcium is in ionized state. It passes through the placental barrier and is excreted into the breast milk. Is excreted from the body, mainly by the kidneys.

Indications

Active ingredient

Composition

1 ml of solution for injection contains:

the active ingredient:

calcium gluconate 10 mg

How to take, the dosage

Intravenously or intramuscularly, adults and children over 14 years of age are administered 5-10 ml of Calcium gluconate daily, every other day or every two days, depending on the nature of the disease and the patient’s condition.

The ampoule with the solution is heated to body temperature before injection. The solution is administered slowly, for 2-3 minutes.

In children, depending on their age, 10 % solution of calcium gluconate is administered intravenously in the following doses: up to 6 months of age – 0.1-1 ml, 6-12 months – 1-1.5 ml, 1-3 years – 1.5-2 ml, 4-6 years – 2-2.5 ml, 7-14 years – 3-5 ml.

In order to administer a solution in an amount less than 1 ml a single dose is adjusted to the appropriate volume (syringe volume) with 0.9% isotonic sodium chloride solution or 5% glucose solution.

Interaction

Calcium gluconate eliminates inhibition of neuromuscular transmission after the use of antibiotics of aminoglycosides series. When used together with thiazide diuretics it leads to the development of hypercalcemia. During the treatment with cardiac glycosides parenteral administration of the drug promotes enhancement of cardiotoxic effects of cardiac glycosides. When concomitant use with phenygidine, calcium preparations weaken its effect. Calcium preparations increase the toxicity of quinidine.

Thiazide diuretics decrease urinary calcium excretion, which increases the risk of hypercalcemia. Calcium preparations are contraindicated in patients receiving cardiac glycosides. Calcium preparations can decrease absorption of tetracyclines in gastrointestinal tract, therefore the interval between the intake of these preparations should be not less than 3 hours.

Special Instructions

Patients with hypercalciuria, decreased glomerular filtration or a history of nephrourolithiasis should prescribe the drug with caution and under control of urinary calcium content.

To reduce the risk of nephrourolithiasis, adequate fluid intake is recommended.

Before filling the syringe with calcium gluconate solution, make sure there is no residual ethyl alcohol in the syringe, because calcium gluconate precipitates when they interact.

The ability to affect reaction speed when driving or operating other machinery. There are no references to the fact that Calcium gluconate may affect the speed of psychomotor reactions.

Contraindications

Side effects

Sometimes there may be nausea, vomiting, diarrhea, bradycardia, a feeling of heat in the mouth and later in the whole body, which quickly pass on their own.

Overdose

Symptoms: Hypercalcemia may occur.

Treatment: As an antidote calcitonin is used, which is administered intravenously at the rate of 5-10 IU per 1 kg of body weight per day (the drug is diluted in 500 ml of 0.9% sodium chloride solution, injected by drip for 6 hours in 2-4 sessions).

Similarities