Calcium-D3 Nicomed forte lemon, 120 pcs.

Pharmacodynamics

It regulates calcium and phosphorus metabolism in the body (bones, teeth, nails, hair, muscles). It reduces resorption (resorption) and increases bone density, filling the lack of calcium and vitamin D3 in the body and is necessary for the mineralization of teeth.

Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood clotting system.

Vitamin D3 increases the absorption of calcium in the intestine.

The use of calcium and vitamin D3 inhibits increased production of parathyroid hormone (PTH), which is a stimulant of increased bone resorption (leaching of calcium from bones).

Pharmacokinetics

Calcium

absorption. Normally, the amount of calcium absorbed in the gastrointestinal tract is about 30% of the dose taken.

Distribution and metabolism. 99% of calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is in intra- and extracellular fluids.

About 50% of the total calcium in the blood is in the physiologically active ionized form, of which about 10% is complexed with citrate, phosphate or other anions; the remaining 40% is associated with proteins, primarily with albumin.

Elimination. Calcium is excreted by the intestines, kidneys, and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Intake.Vitamin D3 is readily absorbed in the small intestine (about 80% of the dose taken).

Distribution and metabolism. Coleciferol and its metabolites circulate in the blood, bound to specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolecalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycolecalciferol. 1,25-hydroxycalciferol is the metabolite responsible for increasing calcium absorption. Unmetabolized vitamin D3 is deposited in fat and muscle tissue.

Elimination. Vitamin D3 is excreted by the intestine and kidneys.

Indications

Prevention and treatment of calcium and/or vitamin D3 deficiency;
Prevention and complex therapy of osteoporosis (menopausal, senile, steroid, idiopathic).

Pharmacological effect

Pharmacodynamics

Regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body, necessary for the mineralization of teeth.

Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.

Vitamin D3 increases calcium absorption in the intestines.

The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).

Pharmacokinetics

Calcium

Suction. Typically, the amount of calcium absorbed in the gastrointestinal tract is approximately 30% of the dose taken.

Distribution and metabolism. 99% of the calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is found in intra- and extracellular fluids.

About 50% of the total calcium content in the blood is in physiologically active ionized form, of which approximately 10% is complexed with citrate, phosphate or other anions, the remaining 40% is associated with proteins, primarily albumin.

Excretion. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Suction. Vitamin D3 is easily absorbed in the small intestine (about 80% of the dose taken).

Distribution and metabolism. Colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolecalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycolecalciferol. 1,25-hydroxycolecalciferol is a metabolite responsible for increasing calcium absorption. Unmetabolized vitamin D3 is stored in adipose and muscle tissue.

Excretion. Vitamin D3 is excreted by the intestines and kidneys.

Active ingredient

Calcium carbonate, Colecalciferol

Composition

1 tablet contains:

Calcium carbonate 1250 mg (corresponds to 500 mg calcium)

Colecalciferol (vitamin D3) 400 IU

Excipients:

Sorbitol

Isomalt

Povidone

Magnesium stearate

Aspartame

Lemon oil

Mono- and diglycerides of fatty acids.

Pregnancy

The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child.

Vitamin D and its metabolites can pass into breast milk, so it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child.

Contraindications

Hypersensitivity to the components of the drug
Hypercalcemia, hypercalciuria
Nephrolithiasis
Vitamin D hypervitaminosis
Severe renal failure
Active form of tuberculosis
Sarcoidosis
Children under 3 years of age.

With caution: pregnancy; lactation period.

Side Effects

Allergic reactions
Gastrointestinal dysfunction (constipation or diarrhea, flatulence, nausea, abdominal pain)
Hypercalcemia and hypercaliciuria.

Storage conditions

In a place protected from light, at a temperature not exceeding 25°C, in tightly closed packaging.

Shelf life

3 years.

Manufacturer

Takeda Pharmaceuticals LLC, Russia