Calcigard Retard, 20 mg 100 pcs

Angina pectoris, arterial hypertension

Active ingredient

Nifedipine

Composition

Active substance:

nifedipine 20 mg,

Supplementary substances:

Lactose;

Starch;

MCC;

Tween-80;

Polyethylene glycol;

stearic acid;

PVP;

magnesium stearate

sodium lauryl sulfate.

How to take, the dosage

Calcigard retard is taken orally, the dosing regimen is set individually.

The average dose is 1 tablet (20 mg) 2 times daily with some fluid during or after meals.

In case of insufficient clinical effect, the dose can be gradually increased.

The maximum dose is 40 mg 2 times daily.

Interaction

When Calcigard Retard and:

• beta-adrenoblockers, other antihypertensive drugs, tricyclic antidepressants, diuretics, vasodilators – the hypotensive effects of the drug are increased;
• in combination with nitrates tachycardia and increased hypotensive effect are observed; diltiazem – clearance of nifedipine decreases. When using such a combination, the dose of Calcigard Retard should be reduced and patients should be closely monitored;
• antiarrhythmic drugs (e.g., amiodarone and quinidine) – their negative inotropic effect may increase;
• digoxin decreases digoxin clearance, increases plasma levels of digoxin and the risk of digoxin intoxication. In these cases, doses of digoxin should be reduced and plasma levels checked;
• theophylline may increase plasma levels of theophylline, requiring dose adjustment;
• cimetidine and, to a lesser extent, ranitidine may increase plasma levels of nifedipine and enhance its effects;
• vincristine makes it difficult to eliminate the latter from the body, which increases the risk of increased side effects caused by vincristine;
• cephalosporins increase the bioavailability of cephalosporins.

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Contraindications

• low blood pressure below 90 mmHg
• severe heart failure
• high sensitivity to the drug Calcigard retard.

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Side effects

Cardiovascular system disorders: possible – facial hyperemia, fever, tachycardia, peripheral edema, arterial hypotension. Special indications – in some patients, especially at the beginning of treatment, angina pectoris may occur, which requires discontinuation of the drug.

Central nervous system disorders: headache, dizziness, increased fatigue, somnolence. While using high doses of the drug single cases of paresthesia of extremities, tremor, light vision disorders, sleep disorders have been noted.

Gastro-intestinal tract and liver disorders: nausea, constipation, diarrhea. With long-term use of the drug some cases of increased activity of liver transaminases in the blood serum and intrahepatic cholestasis may occur.

With the hematopoietic system: in rare cases – reversible thrombocytopenia, leukopenia, anemia.

Urinary system disorders: increase in daily urine output; in patients with renal failure – deterioration of renal function.

Allergic reactions: rarely – urticaria, skin itching.

Others: with long-term use – myalgia, gynecomastia, gum hyperplasia, hyperglycemia.

Overdose

Symptoms: marked arterial hypotension, heart rhythm disturbances (bradycardia or tachycardia). With increasing phenomena of intoxication hypoxia, cardiogenic shock, disorders of consciousness may occur.

Treatment: gastric lavage, activated charcoal, intravenous administration of calcium salts. Treatment is symptomatic. Hemodialysis is not effective.

Similarities

Cordaflex, Corinfar, Corinfar Retard, Cordypine XL, Nifedipine, Phenigidine, Nifecard XL