Calcemin Advance, 120 pcs.

A combined product containing vitamins, micro- and macro-nutrients.

The action is caused by the properties of the ingredients.

Indications

Prevention and complex treatment of osteoporosis of different genesis:

– in women during menopause (natural and surgical);

– in persons taking long-term GCS and immunosuppressants.

Therapy of musculoskeletal system disorders (to improve consolidation of traumatic fractures).

To replenish calcium and trace element deficiencies in adolescents.

Composition

Active ingredients:

calcium (calcium citrate and calcium carbonate) 500 mg,

colocalciferol (vitamin D3) 200 IU,

magnesium 40 mg,

zinc 7.5 mg,

copper 1 mg,

manganese 1.8 mg,

boron 250 µg.

Associates:

maltodextrin 25 mg,

microcrystalline cellulose 49, 05 mg,

croscarmellose sodium 38 mg,

stearic acid 16, 3 mg,

soy polysaccharide 15 mg,

sodium lauryl sulfate 5 mg.

Shell:

Hypromellose 26, 328 mg, titanium dioxide 12, 643 mg, magnesium silicate 5 mg, triacetin 5, 689 mg, mineral oil 2, 845 mg, dye red #40 (dye red charming) 0, 316, dye yellow #6 (sunset yellow) 0, 079 mg, dye blue #1 0, 04 mg.

Description:

The tablets are biconvex oval-shaped, coated with a pink coating with a rib on one side.

How to take, the dosage

Take orally, with meals.

The complex therapy of osteoporosis – 1 tablet 2 times a day.

Prevention of osteoporosis – 1 tablet a day.

When taking the preparation for prophylaxis and in complex therapy of osteoporosis the duration of treatment is determined by the doctor individually. Average course duration for prophylaxis is 2 months and for treatment of osteoporosis – 3 months.

Therapy of musculoskeletal system disorders: to improve the consolidation of traumatic fractures – 1 tablet a day, the duration of treatment is 4-6 weeks.

To replenish calcium and trace elements deficiency in adolescents from 12 years of age – 1 tablet a day. The average duration of treatment is 4-6 weeks.

Interaction

The toxicity of vitamin D3 is reduced when Calcemin is used concomitantly with vitamin A.

Phenytoin, barbiturates, GCS reduce the effectiveness of vitamin D3.

Laxatives decrease absorption of vitamin D3.

GCS, hormonal contraceptives for systemic use, levothyroxine impair absorption of calcium ions.

If tetracyclines are used concomitantly, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) – at least 2 hours.

In co-administration of Calcemin with cardiac glycosides increases their toxicity (ECG and clinical monitoring is necessary), with thiazide diuretics – the risk of hypercalcemia increases, with furosemide and other loop diuretics – renal calcium excretion increases.

Do not use Calcemin simultaneously with calcium channel blockers.

The combined use of the drug with antacids containing aluminum is not recommended due to a decrease in their effectiveness.

Special Instructions

The dose should not exceed the one indicated in the instructions because increased calcium intake may inhibit the absorption of iron, zinc, and other essential minerals in the intestine.

Synopsis

Contraindications

– individual hypersensitivity to the components of the drug,

– hypervitaminosis of vitamin D,

– active tuberculosis,

– hypercalcemia and hypercalciuria,

– severe renal insufficiency,

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– nephrolithiasis,

– sarcoidosis,

– childhood (under 12 years),

– urolithiasis,

– allergic reaction to peanut butter and soy because the drug contains polysaccharide soy.

Cautious:pregnancy and lactation, renal failure.

Overdose

Vitamin D hypervitaminosis, hypercalcemia, and hypercalciuria.

Symptoms: fainting, constipation, headache, coma, decreased appetite, thirst, polyuria, dizziness, nausea and vomiting, muscle weakness, increased fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, urolithiasis, in severe cases, cardiac arrhythmias. If the first signs of overdose are detected, reduce the dose or stop using the drug, consult a doctor.

In prolonged use in doses over 2500 mg of calcium – kidney damage, calcinosis of soft tissues. If hypercalciuria exceeds 7.5 mmol/day (300 mg/day), the dose should be reduced or the drug should be discontinued.

Treatment: Rehydration, use of loop diuretics (e.g., furosemide), glucocorticosteriods, calcitonin, bisphosphonates, in severe cases hemodialysis. In this case it is necessary to reduce the dose or stop using the drug. In case of accidental overdose it is necessary to induce vomiting, gastric lavage. Therapy is symptomatic. In case of accidental overdose, vomiting and gastric lavage should be induced. Therapy is symptomatic.

Pregnancy use

During pregnancy and breast-feeding the drug administration should be coordinated with a physician. In breast-feeding women it should be taken into account that colecalciferol and its metabolites penetrate into the breast milk, therefore it is necessary to consider the intake of calcium and vitamin D3.

The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3, hypergalcemia developing against overdose during pregnancy can cause defects of mental and physical development in the fetus.