Bystromgel, gel 2.5% 30 g

Pharmacodynamics

PNPS, propionic acid derivative. It has analgesic and anti-inflammatory effect.

Inhibiting COX-1 and COX-2, inhibits the synthesis of prostaglandins. It has anti-bradykinin activity, stabilizes lysosomal membranes. It reduces the release of cytokines and inhibits the activity of neutrophils.

In joint syndrome, it relieves joint pain at rest and on movement, reduces morning stiffness and joint swelling, helps increase range of motion.

Pharmacokinetics

Assimilation

. When the gel is applied externally, there is extremely slow transdermal absorption of ketoprofen, which ensures that its concentration in the inflamed tissues is maintained within therapeutic levels for a long time. Absorption into the systemic bloodstream is insignificant. It practically does not cumulate. The bioavailability of the gel is about 5%.

Distribution

Ketoprofen penetrates well into the synovial fluid and connective tissue.

Indications

Inflammatory or traumatic lesions of joints, tendons, ligaments and muscles:

arthritis, periarthritis;
tendinitis, tenosynovitis;
bursitis;
bruises, ligament damage, dislocations, damage to the meniscus of the knee;
torticollis;
lumbago.

Phlebitis, periphlebitis.

Pharmacological effect

Pharmacodynamics

NSAID, propionic acid derivative. Has an analgesic and anti-inflammatory effect.

By inhibiting COX-1 and COX-2, it inhibits the synthesis of prostaglandins. It has anti-bradykinin activity and stabilizes lysosomal membranes. Reduces the release of cytokines, inhibits the activity of neutrophils.

In case of articular syndrome, it relieves pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints, and helps to increase the range of movements.

Pharmacokinetics

Suction

When the gel is applied externally, extremely slow transdermal absorption of ketoprofen occurs, which ensures that its concentration in inflamed tissues is maintained within a therapeutic level for a long time. Absorption into the systemic circulation is negligible. Practically does not accumulate. The bioavailability of the gel is about 5%.

Distribution

Ketoprofen penetrates well into synovial fluid and connective tissue.

Special instructions

It is not recommended to apply the gel to open wounds or damaged areas of skin.

Do not allow the gel to come into contact with mucous membranes or eyes.

Active ingredient

Ketoprofen

Composition

Active ingredients:

ketoprofen 25 mg.

Excipients:

ethanol (ethyl alcohol) rectified,

nipagin,

carbomer,

trometamol,

lavender oil,

neroli oil,

purified water.

Pregnancy

The drug is contraindicated for use during pregnancy and lactation.

Contraindications

Hypersensitivity to ketoprofen or other components of the drug;
dermatoses;
eczema;
infected abrasions and wounds;
pregnancy and lactation;
childhood.

Side Effects

In isolated cases: allergic reactions that require discontinuation of the drug, photosensitivity.

Interaction

Currently, no cases of drug interactions between Bystrumgel® and other drugs have been identified.

Overdose

There are no cases of overdose with the use of Bystrumgel®.

Storage conditions

Store in a dry place, protected from light, out of reach of children, at a temperature of 15° to 25°C.

Shelf life

2 years.

Manufacturer

Akrikhin JSC, Russia