Broxinac, eye drops 0.09% 2.5ml

Bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic effects, blocks the synthesis of prostaglandins from arachidonic acid, by inhibiting cyclooxygenase 1 and 2, resulting in reduced inflammation and pain response.

In vivo studies have shown that prostaglandins mediate some types of ocular inflammation. In animal studies, prostaglandins contributed to disruption of the blood-ophthalmic barrier, increased vascular permeability, caused vasodilation, leukocytosis, and increased intraocular pressure.

Pharmacokinetics

The drug concentration in plasma is well below the limit of measurement and has no clinical significance.

Bromfenac effectively penetrates into the cornea: with single instillation, the concentration in the aqueous humor of the eye is 79±68 ng/ml after 150-180 minutes after administration of the drug. This concentration persists for 12 hours in the aqueous humor of the eye with retention of therapeutically significant concentration in the tissues of the eye, including the retina, for up to 24 hours.

The half-life from the aqueous humor of the eye is about 1.4 hours.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

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Overdose