Bromhexin, tablets 8 mg 20 pcs

Pharmacodynamics

Bromhexin has mucolytic (secretolytic) and expectorant (secretomotor) effects as well as a mild anti-cough effect. It reduces the viscosity of sputum, activates the permeable epithelium, increases the volume of sputum and improves its discharge. Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during breathing. The effect is seen in 2-5 days after the start of treatment.

Pharmacokinetics

In oral administration, it is almost completely (99%) absorbed in the gastrointestinal tract (GIT) within 30 minutes. Bioavailability is about 80%. Binds to plasma proteins by 99%. It penetrates through placental and blood-brain barrier. It penetrates into breast milk. It undergoes demethylation and oxidation in the liver; it is metabolized to ambroxol. The elimination half-life is 15 hours (due to slow reverse diffusion from tissues). It is excreted by the kidneys as metabolites. In chronic renal failure (CKD), excretion of metabolites is impaired. With repeated use it may cumulate.

Indications

Acute and chronic bronchopulmonary diseases accompanied by high viscosity sputum formation (bronchial asthma, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, pulmonary emphysema, cystic fibrosis, tuberculosis, pneumoconiosis).

Active ingredient

Composition

1 tablet contains:
active ingredient: bromhexine hydrochloride – 8 mg.

How to take, the dosage

Bromhexin is taken orally regardless of meals. Adults are prescribed 1 to 2 tablets 3 to 4 times a day; children from 3 to 5 years – 2 mg, from 6 to 14 years – 4 mg three times a day. The course of treatment is from 4 to 28 days.
During treatment, it is recommended to drink a sufficient amount of fluid, which supports the secretolytic action of Bromhexin.

Interaction

Bromhexin may be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

When Bromhexin is used in combination with cough suppressants (including those containing codeine), there may be a risk of congestion due to weakening of the cough reflex.

Bromhexin promotes penetration of antibiotics (erythromycin, cephalexin, oxytetracycline, ampicillin, amoxicillin) into lung tissue.

Special Instructions

In cases of impaired bronchial motility or with a significant volume of sputum secreted, the use of the drug Bromhexin requires caution due to the risk of retention of secretions in the airways.

In the course of treatment, drinking plenty of fluids is recommended to increase the secretolytic effect of Bromhexin.

In severe renal failure, the possibility of cumulation of metabolites formed in the liver must be considered.

In children, treatment should be combined with postural drainage or vibration chest massage to facilitate removal of the secretion from the bronchi.

The effect of the drug on driving and operating machinery

At the time of treatment, caution should be exercised while driving vehicles and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity to bromhexine and other components of the drug;

Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

Gastric and duodenal ulcer (acute stage);

pregnancy (first trimester);

children under 3 years of age.

With caution

renal and/or hepatic failure;

In bronchial motility disorders accompanied by excessive secretion;

with a history of prone to gastric bleeding.

Side effects

Digestive system disorders:

Infrequent: nausea, vomiting, diarrhea, abdominal pain;

Immune system disorders:

Infrequent: fever, hypersensitivity reactions (skin rash, angioedema, respiratory failure, itching, urticaria);

Very rare: anaphylactic reactions up to shock.

Skin and subcutaneous tissue disorders:

very rarely: Stevens-Johnson syndrome.

In case of side effects, the drug should be stopped and a doctor should be consulted.

Overdose

Symptoms: nausea, vomiting and other gastrointestinal disorders.

Treatment: there is no specific antidote. In case of overdose it is necessary to induce vomiting, and then the patient should be given fluids (milk or water). Gastric lavage is recommended within 1-2 hours after taking the drug.

Similarities